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Friday 15 April 2022

Phytochemical Tocopherols Have No Effects on Platelet Aggregation in Patients with Metabolic Syndrome

By Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndromes you have metabolic syndrome.

According to statistics, in the US, 30% of Americans are living with metabolic syndrome,

and, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

There are certain risk factors associated with the onset of metabolic syndrome besides the five mentioned above including age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Untreated metabolic syndrome epidemiologically may induce complications of chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.

Platelet aggregation is a condition of platelets clumping together in the blood. The process also is necessary for the cover of vascular injury.


Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cardiovascular diseases and diabetes, researchers examined the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. 

A randomized, double-blind, crossover, and the placebo-controlled trial included 32 metabolic syndrome adults supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days and consumed 200 mg PTT mixture or placebo capsule after a meal, after 14 days,  after15-day washout period.

Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) which is essential to the flow of energy in living cells, did not show substantial changes after supplementation with PTT mixture compared to placebo.

There are no changes in postprandial platelet aggregation reactivity compared to PTT mixture and placebo interventions.

Based on the findings, researchers said, "The results of this study highlight the lack of inhibitory effect on platelet aggregation after short-term supplementation of PTT mixture in participants with metabolic syndrome".

Taken altogether, tocopherols have no effect on platelet aggregation in patients with metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial by Gan YL1,2, Fu JY3, Lai OM1,4, Chew BH5, Yuen KH6, Teng KT2, Nesaretnam K2, Selvaduray KR2, Meganathan P. (PubMed)

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