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Monday, 7 September 2020

Collard Greens' Sulforaphane (SFN), Protects the Neuron Against Neurodegenerative Diseases

By Kyle J. Norton

 Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

American typical diet contains a high amount of saturated and trans fat, artificial ingredients with fewer fruits and vegetable which can lead to dementia and other kinds of diseases.

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.

Neuroprotection an action involved the use of a natural substance to protect the integrity of neurons against damage or death.

In other words, neuroprotection is the process to protect brain functioning.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical condition, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases

A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.

Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.

Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.

According to the WHO, neurological disorders, ranging from epilepsy to Alzheimer's disease, from stroke to headache, affect up to one billion people worldwide.

Sulforaphane (SFN), a phytochemical found abundantly in the species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin.

On finding a potential plant for the prevention of dementia, researchers examined the neuroprotective effects of isothiocyanate sulforaphane (SFN), and erucin (ERN) isolated from collard greens.

According to the tested analysis, in the comparison of the neuroprotective effects of SFN and ERN in SH-SY5Y cells.at the same dose level (5 μM) with oxidative stress induced by 6-hydroxydopamine (6-OHDA), the pretreatment of the SH-SY5Y cells with SFN showed a significant increase of the levels of active nuclear Nrf2 protein associated with the expression of antioxidant enzymes produced by the host.

Furthermore, pretreatment of SFN not only improved the levels of total GSH (antioxidants) but also protected the neuron against apoptosis elicited by 6-OHDA compared to ERN.

Interestingly, the simultaneous treatment of SH-SY5Y cells with either SFN or ERN and 6-OHDA showed similarly neuroprotective effects as those of pretreatment of SFN.

Similar results were also found in the mouse model.

Based on the findings, researchers said, "The metabolic oxidation of ERN to SFN could account for their similar neuroprotective effects in vivo, raising the possibility of using vegetables containing a precursor of ERN for systemic antioxidant benefits in a similar manner to SFN".

Taken altogether, phytochemical SFN phytochemicals may be considered a supplement for the prevention and treatment of neurodegenerative diseases, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in Vitro and in Vivo Models of Parkinson's Disease by Morroni F1, Sita G1, Djemil A2, D'Amico M3, Pruccoli L3, Cantelli-Forti G3, Hrelia P1, Tarozzi A. (PubMed)

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