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Thursday, 23 July 2020

Omega -3 Fatty Acids Might Block the Onset of Breast Cancer

By Kyle J. Norton

The woman breast is made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a woman's breast is totally determined by the amount of fat.

Cancer is a class of chronic condition characterized by irregular cell growth associated with the alternation of cell DNA.

Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

In the early stage, most patients with breast cancer may experience lumps on the breast or surrounding the breast.

However, breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.

At the later stage, after colonizing most parts of the breast, the breast cancer cells may travel a distance far the way to infect other healthy cells and tissue.

According to the statistics, the lifetime risk of invasive breast cancer developing is 12%.

In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

Just about 20% of breast cancers are diagnosed in women under 50, while almost 30% are diagnosed in women over 70 years of age.

The 5 years survival rate of breast cancer diagnosed at the early stage is closed to 100%.

Epidemiologically, there are several factors that can reduce the risk of breast cancer including breastfeeding, early age at first full-term pregnancy, an increasing number of births, preeclampsia, longer duration of breastfeeding.

The stages of breast cancer can be classified depending on
* The size of the cancer
* Invasive or not
* Whether cancer has spread to the lymph nodes
* Whether cancer has spread to the distance parts or organs of the body.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of malignant tumors, researchers compared the effect of DHA, Delta-T3, and DHA plus Delta-T3 co-treatment on triple-negative breast cancer cell line MDA-MB-231.

Based on the results of cells treated by 50 μM DHA and/or 5 μM Delta-T3,
* DHA can trigger an increase in lipid droplet (LD) biogenesis and co-treatment with Delta-T3 was able to reduce this LD biogenesis.

Please note that a higher cytoplasmic LD content is associated with a higher breast cancer cell malignancy and proliferation.

* The inhibition of the cytoplasmic LD content by silencing ADRP (adipose differentiation-related protein), also decreased cell proliferation in MDA-MB-231 cells.

* Treatment with DHA and Delta-T3 alone or co-treatment did not reduce cell viability

* More importantly, DHA can trigger lipophagy associated with the autophagic degradation of lipid droplets in MDA-MB-231 cells compared to DHA plus Delta-T3 co-treatment that was able to enhance this lipophagy process.

Based on the findings, researchers said, " co-treatment with DHA plus Delta-T3 in MDA-MB-231 cells could reduce LD biogenesis and potentiate lipophagy in these cells, possibly having a positive impact to inhibit breast cancer malignancy".


Taken altogether, Omega-3 fatty acids together with Delta-T3 vitamin E isoform may be considered a supplementation for the prevention and treatment of breast cancer,  pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega 3-DHA and Delta-Tocotrienol Modulate Lipid Droplet Biogenesis and Lipophagy in Breast Cancer Cells: the Impact in Cancer Aggressiveness by Pizato N1, Kiffer LFMV2,3, Luzete BC4,5, Assumpção JAF6, Correa LH7, Melo HAB8, Sant'Ana LP9, Ito MK10, Magalhães KG.
(PubMed)

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