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Saturday, 25 July 2020

Cabbage Protects the Neuron Integrity Against Neurodegenerative Diseases

By Kyle J. Norton

Neuroprotection an action involved the use of a natural substance to protect the integrity of neurons against damage or death.

In other words, neuroprotection is the process to protect brain functioning.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

The most common diseases associated with neurodegenerative diseases are dementia, a cluster of conditions included Alzheimer’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.

Dementia is a neuropsychiatric disorder as a result of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, contributing to caregiver burden and premature institutionalization.

The true symptoms of dementia are a progressive loss of memory and other mental abilities that can cause impairment of a person's ability to perform usual tasks in everyday life. 

According to the statistics, about 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food for the treatment of age-related diseases, researchers examined the effect of cabbage consumption in the risks of neurodegenerative disease.

According to the tested differentiation,  isothiocyanates (ITCs), the sulfur- and nitrogen-containing phytochemicals found in cabbage reduced the risk for developing neurodegenerative diseases (NDDs) and some other chronic disorders including but not limited to cardiovascular diseases, various forms of cancer and inflammatory disorders among others. 

Furthermore, Sulforaphane(SFN), derived from glucoraphanin EXERTED its ability not only arrest many target proteins but also to control various metabolic pathways in neuronal cells by targeting amyloid β (Aβ)-induced oxidative damage and apoptosis in a human neuroblastoma cell line (SH-SY5Y). 

Moreover, SFN inhibited the progression of Parkinson’s disease (PD) through the interception of pro-inflammatory and apoptotic pathways in vivo, induced by intrastriatal injection of 6-hydroxydopamine (6-OHDA) for 28 days.

Additionally, in the examing the chemical compound moringin (MG) isolated from the leaf extracts of cabbage, researchers found that the administration in different doses improved spatial memory and reduced neuronal degeneration to the minimum level in the hippocampal region of the animal disease model. 

Based on the results, researchers wrote, "This review summarizes the most significant and up-to-date in vitro and in vivo neuroprotective actions of sulforaphane (SFN), moringin (MG), .... in neurodegenerative diseases".

Taken altogether, cabbage processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of neurodegenerative diseases, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Glucosinolates Hydrolytic Products in Neurodegenerative Diseases (NDDs) by Jaafaru MS1,2, Abd Karim NA3, Enas ME4, Rollin P5, Mazzon E6, Abdull Razis AF. (PMC)

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