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Friday 10 July 2020

Broccoli Kills Primary Effusion Lymphoma (PEL) Cells in Vitro

By Kyle J. Norton

Lymphoma is a medical and chronic condition associated with abnormal growth of lymphocytes, a type of white blood cells of the immune system that fights infection.

Lymphocytes included natural killer cells T cells and B cells are found in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body.

According to the statistics, in the US, this year, approximately, 8,000 people will be diagnosed with Hodgkin lymphoma, leading to the death of 1,000 patients with the disease.

Non-Hodgkin's lymphomas are the most common types of lymphoma

According to statistics provided by the Leukemia and Lymphoma Society, in the US, approximately over 1,30,000 people are either living with or are in remission from, leukemia, lymphoma or myeloma, causing the death of over 9% of all cancer death in 2018.

60 years of age and over, weakened immune system, previous exposure to toxic chemicals, previous chemotherapy or radiation therapy are some of the most common prevalent factors of lymphoma.

Interestingly, most people with some of the above risk factors have never developed lymphoma.
Believe it or not, Hodgkin's lymphoma is treatable, especially in its early stages. The 5-year survival rate for all patients diagnosed with Hodgkin's lymphoma is 92%.

Primary effusion lymphoma (PEL) is a rare subtype of non-Hodgkin's B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV) in immunosuppressed patients.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticancer activity, researchers examined the effects sulforaphane (SF), on primary effusion lymphoma (PEL).

According to the analysis, SFN decreased the viability of KSHV-infected PEL cells compared to KSHV-uninfected B-lymphoma cells.

SFN demonstrated the anti-proliferative effects on PEL cells by activating caspases involved in cancer cell apoptosis.

Furthermore, SFN also inhibited the activated p38MAPK and AKT signaling to induce apoptosis against cancer cell survival and proliferation.

Collectively, researchers said, "the anti-proliferative effects of SFN indicate its potential as a new substance for the treatment of PEL".

Taken altogether, broccoli processed a high amount of SFN, may be considered a functional food for the treatment of Primary effusion lymphoma (PEL),  pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion LymphomaCells by Suppressing p38MAPK and AKT Phosphorylation by Ishiura Y1, Ishimaru H1, Watanabe T1, Fujimuro M. (PubMed)

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