Tocopherols Inhibit the Onset of Seizure

By Kyle J. Norton

Epilepsy is a condition of a neurological disorder caused by abnormal electrical activity in the brain inducing sudden recurrent episodes of sensory disturbance and convulsions.

A seizure is a sudden, uncontrolled electrical disturbance in the brain, leading to changes in a person's behavior, movements or feelings, and levels of consciousness in the short term.

Patients with two or more seizures or a tendency of recurrent seizures are having epilepsy.

Seizures are not a disease in themselves. Instead, they are a symptom of many different diseases that can affect the brain. Some seizures may have unknown causes.

A neurological examination was done in a doctor’s office that can be helpful in the diagnosis of a seizure by examing the nervous functioning.

However, an EEG test or electroencephalogram that examines the electrical activity of the brain by looking into certain patterns on the EEG that orchestrates typical of epilepsy. 

Seizures are classified into two groups
* Generalized seizures affect both sides of the brain, including
** Absence seizures that cause rapid blinking or a few seconds of staring into space.

 ** Tonic-clonic seizures.

** Lose consciousness.

* Focal seizures are located in just one area of the brain., including

** Simple focal seizures affect a small part of the brain.

** Complex focal seizures can make a person with epilepsy confused or dazed. 

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of epilepsy, researchers examined the vitamin E (as α-tocopherol, α-T) a neuroprotective and anti-inflammatory effect on epilepsy,

According to the analysis of rat seizures induced by single intraperitoneal injection of kainic acid and, starting from 3 h after status epilepticus, before treated with an intraperitoneal bolus of α-T (250 mg/kg b.w.; once a day) for 4 days.

Post-seizure α-T administration significantly reduced astrocytosis and microglial activation and decreased neuron degeneration and spine loss by lowering lipid peroxidation in the hippocampus.

These results suggested α-T administration exerted the anti-inflammatory and neuroprotective activity in kainic acid-induced epilepsy.

Furthermore, post-seizure treatment with α-T provides effective secondary prevention against post-seizure inflammation-induced brain damages and possibly against their epileptogenic effects.

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of seizure pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Post-seizure α-tocopherol treatment decreases neuroinflammation and neuronal degeneration induced by status epilepticus in rat hippocampus by Ambrogini P1, Minelli A, Galati C, Betti M, Lattanzi D, Ciffolilli S, Piroddi M, Galli F, Cuppini R. (PubMed)