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Friday, 8 May 2020

Devil's claw (Harpagophytum procumbens) Processes Anti Inflammatory Bowel Disease (IBD) Potential

By Kyle J. Norton

Inflammatory Bowel Disease is a condition characterized by long term inflammation of the gut.

Most common types of IBD are
*Crohn’s disease (CD) is an inflammation of any part of the digestive tract. Most cases of CD affect the tail end of the small intestine.

* Ulcerative colitis is an inflammation of the large intestine.

The exact causes of inflammatory bowel disease are unknown. As of today, scientists do not know why, people with the same health conditions, are susceptible to the onset of the disease, while others do not.

Some researchers suggested that the disease may be caused by the immune response failing to kill off the invasion of infectious micro-organisms in the acute phase of digestive tissue injury and damage or immune dysfunction mistakenly attacking the digestive tract, a case of autoimmune disease.

Genetic mutation inherited from the parents such as NOD2, ATG16L1and IL23R involved in innate immunity, in the autophagy, and in the inflammatory response may elevate the risk of IBD


Furthermore, prolonged periods of imbalance of the ratio of good and bad bacteria in the colon, long-term intake of certain medicines, age, family history, ethnicity, parasite, unhealthy diet, and smoking are some prevalent risk factors that can lead to the onset of inflammatory bowel disease.

The most common symptoms of inflammatory bowel disease are severe diarrhea, abdominal pain, fatigue, and weight loss. 

Believe it or not, if you are living in the Western world, you are also at a higher risk of the disease. For example, people who live in Western countries such as the United States and Europe have a higher IBD risk than those in other parts of the world.

Some researchers suggested an individual diet pattern may influence the risk of IBD.

According to the statistics provided by the CDC, inflammatory bowel disease Prevalence (IBD) affects approximately 1.3% of US adults (3 million)in 2015.


On finding a natural ingredient for the prevention and treatment of colonic diseases, scientists compared the antioxidant effects of Devil's claw and Aminosalicylates (5-ASA) in cell-free oxidant-generating systems and inflamed human colorectal biopsies.

Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa. 

The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.

According to tested analysis,
* Like 5-ASA, Devel's claw showed a strong effect in scavenged superoxide dose-dependently.

* Devil's claw demonstrated the decreased oxygen radical release, after incubation with the tested cell lines.

Based on the results, researchers suggest, "...devil's claw, ...merit(s) formal evaluation as novel therapies in inflammatory bowel disease.".

Taken altogether, Devil's claw may be considered a remedy for the treatment of inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study by Langmead L1, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS. (PubMed)

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