Ursolic Acid Inhibits the Onset of Insulin Resistance in Vitro

By Kyle J. Norton

Insulin resistance is a condition in which cells that convert glucose to energy in the muscles, body fat, intestine, and liver ignore the signal of the hormone insulin signaling.

In other words, patients with insulin resistance are hyperglycemic. The syndrome is a hallmark of type 2 diabetes.

Epidemiologically, people with insulin resistance are associated with an increased risk of prediabetes, type 2 diabetes and chronic conditions such as heart attacks, strokes, and cancer.

Most cases of insulin resistance in the Western world are involved in the clogged up insulin receptors.
As the signals of hormone insulin are blocked, insulin resistance develops, leading to more production of insulin by the body.

According to statistics, over 100 million Americans are living with insulin resistance. Approximately 1 in 3, including half of those aged 60 and older have a silent blood sugar problem known as insulin resistance.

There are no single causes of insulin resistance. Epidemiologically, aging, ethnicity, overweight or obese, too much belly fat, physical inactivity, smoking and certain medical conditions such as Cushing’s disease or polycystic ovary disease are some of the prevalent factors that induce the risk of the condition.

However, most people with some of the aforementioned risk factors have never developed insulin resistance.

The most common symptoms of patients with insulin resistance are tiredness, hunger and difficulty concentrating.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the ursolic acid effects on insulin resistance (IR) and inflammation induced by the excess of visceral adipose tissue (VAT) in obese.

The study included 40 male Wistar rats that were randomly assigned to eight groups (n = 5).
* One group was used for time 0.

* Three groups were labeled as OBE (control): receiving high-fat diet (HFD; fat content 45.24% of energy) during 3, 6, or 9 weeks;

* Three groups UA-PREV: exposed to simultaneous HFD and UA during 3, 6, or 9 weeks to evaluate UA preventive effects;

* One group UA-REV: receiving HFD for 6 weeks, followed by simultaneous HFD and UA for three additional weeks to analyze UA reversal effects.

According to the analysis of the measurements were performed after 3, 6, or 9 weeks of treatment,

* UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels.
* UA also inhibited the VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), the key chemokines that regulate migration and infiltration.

* UA induced the increase of anti-inflammatory proteins IL (interleukin)-1β and IL-6, in the adiponectin levels.
* UA metabolic effects demonstrated in this study support its potential therapeutic utility to improve IR, and inflammation observed in obesity and diabetes.

Taken altogether, ursolic acid may be considered adjunct therapies in the prevention and treatment of insulin resistance (IR) and inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Ursolic Acid on Insulin Resistance and Hyperinsulinemia in Rats with Diet-Induced Obesity: Role of Adipokines Expression by González-Garibay AS1, López-Vázquez A1, García-Bañuelos J2, Sánchez-Enríquez S3, Sandoval-Rodríguez AS2, Del Toro Arreola S1, Bueno-Topete MR1, Muñoz-Valle JF4, González Hita ME5, Domínguez-Rosales JA1, Armendáriz-Borunda J2,6, Bastidas-Ramírez BE. (PubMed)

Elecampane (Inula helenium) Exerts cytotoxicity in Acute Lymphoblastic Leukemia (ALL) Cell Lines

By Kyle J. Norton

Cytotoxicity is the process in the induction of cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.

In normal cells, cytotoxicity can cause the death of healthy cells

In cancer cells, cytotoxicity can be benefits to humans by destroying the cancer cells and prevent them from proliferation.

Most cases of cytotoxicity of a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.

In other words, the aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.

Before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

On finding a natural ingredient for the prevention and treatment of leukemia, scientists examined the effects of Ergolide isolated from Inula oculus Christi against leukemic cell lines.

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* Ergolide induced cytotoxic effect on the tested cells by increasing the ROS production during early hours after treatment of cells followed by cell cycle arrest in G0/G1 phase and autophagy induction.
* However, Ergolide did not exert anti cytotoxicity against non-tumorous cells and did not cause noticeable hemolysis.

* Interestingly, according to the N-acetyl-L-cysteine (NAC) assay, Ergolide induces cell death through a ROS-dependent manner by altering the expression of pro-apoptotic related genes. 

* Furthermore, Ergolide intensified vincristine cytotoxicity against acute lymphoblastic leukemia (ALL) cell lines.

Based on the results, researchers suggest, "Ergolide could be considered as a potent natural compound against leukemic cells by inducing cell cycle arrest followed by dose-dependent cell death".

Taken altogether, Elecampane processed abundantly Ergolide, may be considered a remedy for the treatment of acute lymphoblastic leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ergolide, a potent sesquiterpene lactone induces cell cycle arrest along with ROS-dependent apoptosis and potentiates vincristine cytotoxicity in ALL cell lines by Yami A1, Hamzeloo-Moghadam M2, Darbandi A3, Karami A4, Mashati P4, Takhviji V4, Gharehbaghian A. (PubMed)

Omega-3 Fatty Acids, the Healthy Fat for the Treatment of Myocardial Infarction

By Kyle J. Norton


Stroke is the third leading cause of death. Approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

Stroke is caused by the accumulation of cholesterol and other substances that build up the arterial walls.

 In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, leading to the death of some cells in the brain.

According to the statistics, every year, more than 790,000 people suffer a stroke, including 600,000 of these are first attacks, and 185,000 are recurrent attacks. Most cases of stroke occur in people over the age of 65.

Myocardial infarction (MI) is a medical condition known as heart attacks caused by the blood flow decreases or stops to a part of the heart, leading to the damage to the heart muscle.

In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to the reduced blood flow to the heart.

Prompt treatment can minimize brain damage and potential post disease complications.

The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath and dizziness.

Conventionally, treatment of myocardial infarction is the focus to reduce the damage of the heart muscle accomplished through medical or mechanical means.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of post-stroke, researchers examined the omega-3 eicosapentaenoic acid (EPA) EPA the infarct-limiting effect on experimental models.

The observational study conducted in 100 patients with a reperfused anterior ST-elevation myocardial infarction (STEMI), at hospital admission who are quantified by gas-chromatography the red blood cell proportions of AA, EPA, and the AA: EPA ratio, a valid surrogate for cardiomyocyte membrane content.

According to the results of the tested analysis,

* AA:EPA ratio directly related to acute infarct size (coefficient [95% CI]: 6.19 [1.68 to 10.69], P = 0.008) and inversely to long-term cardiac function (left ventricular ejection fraction [LVEF]) (coefficient [95% CI]: − 4.02 [− 7.15 to − 0.89], P = 0.012), comapred to uintreated control.

* EPA inversely related to acute infarct size (coefficient [95% CI]: − 6.58; [− 11.46 to − 1.70]; P = 0.009), while a direct association with LVEF at follow-up (coefficient [95% CI]: 3.67 [0.25 to 7.08]; P = 0.036) was observed.

In other words, both application omega 3 fatty acids demonstrated protective activity to preserve the neuron against damage immediately after the incidence of stroke.

Additionally, researchers also found, " A low AA: EPA ratio in red blood cells at the time of STEMI is associated with smaller acute infarct size and preserved long-term ventricular function".

Collectively, they said, "Our results are consistent with prior work in experimental models and add to the notion of omega-3 fatty acids as a healthy fat".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of myocardial infarction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nutritional preconditioning by marine omega-3 fatty acids in patients with ST-segment elevation myocardial infarction: A METOCARD-CNIC trial substudy by Sala-Vila A1, Fernández-Jiménez R2, Pizarro G3, Calvo C1, García-Ruiz JM4, Fernández-Friera L5, Rodriguez MD4, Escalera N4, Palazuelos J6, Macías A4, Pérez-Asenjo B4, Fernández-Ortiz A2, Ros E1, Fuster V7, Ibáñez B. (PubMed)

Tocopherols, an Effective Adjunct Therapy Against Drug-Resistant Cancer Cells

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Chemotherapy resistance is the resistance of cancerous) cells to allow them to cancer cells to survive and grow despite anti-cancer therapies.

Multiple drug resistance of cancer cells is a type of cancer cell that resistance to multiple drugs.

An article from Chemocare suggested the possible reasons for chemotherapy resistance:

"* Some of the cells that are not killed by the chemotherapy mutate (change) and become resistant to the drug. Once they multiply, there may be more resistant cells than cells that are sensitive to chemotherapy.

* Gene amplification. A cancer cell may produce hundreds of copies of a particular gene. This gene triggers an overproduction of a protein that renders the anticancer drug ineffective.

* Cancer cells may pump the drug out of the cell as fast as it is going in using a molecule called p-glycoprotein.

* Cancer cells may stop taking in the drugs because the protein that transports the drug across the cell wall stops working.

* The cancer cells may learn how to repair the DNA breaks caused by some anti-cancer drugs.

* Cancer cells may develop a mechanism that inactivates the drug".

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of two novel α-tocopheryl-lipoic acid conjugates (TL1 and TL2) that form stable nanovesicles synthesized for the anticancer drug, doxorubicin (DOX), delivery. Both conjugates were able to form stable nanovesicles.

According to the analysis,
* The encapsulation efficiency similar to those of commonly used anticancer drug, doxorubicin (DOX), in nanovesicles was found to be ∼60% and ∼55% for TL1 and TL2, respectively (TL1-DOX and TL2-DOX).

* The cumulative drug (DOX) release from DOX-encapsulated nanovesicles in response to biological reducing agent glutathione (GSH) was ∼50% and ∼40% for TL1-DOX and TL2-DOX, respectively, over a period of 10 h.

* Furthermore, both TL1-DOX and TL2-DOX delivered the anticancer drug, doxorubicin (DOX), across the DOX-sensitive and DOX-resistant HeLa (HeLa-DOXR) cells in an efficient manner and significantly more efficaciously than the drug alone treatments, especially in HeLa-DOXR cells.

Moreover, the nanovesicle mediated DOX treatment also showed significantly higher cell death when compared to DOX alone treatment in HeLa-DOXR cells.

After talking about other factors into account, researchers said, "we present biocompatible and responsive nanovesicles for efficacious drug delivery to drug-sensitive and drug-resistant cancer cells".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of drug-resistant cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reduction Responsive Nanovesicles Derived from Novel α-Tocopheryl-Lipoic Acid Conjugates for Efficacious Drug Delivery to Sensitive and Drug-Resistant Cancer Cells by Maiti B1,2, Kumar K1,2, Moitra P1,2, Kondaiah P1,2, Bhattacharya S. (PubMed)
(2) Chemotherapy Resistance by Chemocare

Cranberry Improves the Lipid Profiles in Patients with Diabetes and Metabolic Syndrome

By Kyle J. Norton

Fat including cholesterol and triglycerides consists of hydrocarbon molecules.

Cholesterol is the type of fat produced by the liver or from fat intake that plays a critical role in the building of strong cell walls, production of vitamin D and steroid hormones and bile acid to aid digestion in the small intestine.

Accessed cholesterol produced by the liver in a healthy individual is returned to the liver by high-density lipoprotein (HDL).

Overexpression of cholesterol levels in the bloodstream has been linked to plaques accumulation on the arterial walls, a major cause of some forms of heart disease and stroke.

The healthy ratio of HDL/LDL cholesterol is any numbers that are less than 1/4.

Triglyceride is fat in the blood that comes from the outside source used by the body to convert to energy.

Triglyceride is stored in the fat cells used to produced energy between meals and in the case when food is scarce.

Compared to cholesterol, triglycerides in high levels also associated with the risk of heart disease, particularly in people with high levels of LDL and low levels of HDL.

Evolutionally, fat accumulation is considered a defense mechanism in the human body where excess fat is stored when foods are plentiful and release to produce energy when foods are scarce.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of cardiovascular diseases, researchers investigated berries, including cranberry as whole fruits, juices, and purified extracts on lipids and lipoproteins in diabetes and metabolic syndrome.

Berry extracts application showed to improve other lipid profiles, by lowering LDL and increasing HDL cholesterol (C), as well as inhibiting the triglyceride-rich lipoproteins in diabetes and metabolic syndrome in the tested subjects.

Furthermore, in clinical studies, berry extracts lowered the total and LDL-C and increased the HDL-C in participants with elevated blood lipids, type 2 diabetes or metabolic syndrome.

Based on the emerging evidence, researchers said, "colorful berry fruits may thus be included in a healthy diet for the prevention and management of CVD".

Taken altogether, cranberry may be considered a remedy for the normalization of lipid profile, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of Berry Bioactive Compounds on Lipids and Lipoproteins in Diabetes and Metabolic Syndrome by Basu A. (PubMed)

Healthy Foods Cruciferous vegetables Inhibit the Onset of Caused by Genotoxicity

By Kyle J. Norton

Genotoxicity is a process of destruction on a cell's genetic material (DNA, RNA), leading to gene mutation.

In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.

Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.

Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.

The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.

The antigenotoxic activity is a process to inhibit the property of chemical agents that induce damages to the genetic information, leading to mutation,

Cancer is a class of diseases associated with alternation of cell DNA or genetic change of cell.

Not all Genotoxicity is mutagenicity, but all mutagens are genotoxic.

Dr. Shareen H, the lead scientist in the study of "Chapter 18 - Genotoxicity and Cancer" wrote, "Genetic toxicology is the study of chemical and physical perturbations to DNA following exposure to endogenous or exogenous agents. Hazard assessment of engineered nanomaterials involves establishing the ability of these novel materials to induce DNA damage (genotoxicity) and to subsequently initiate tumor formation (carcinogenesis)".

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the protection of cell DNA against damage, researchers examined the effects of cruciferous vegetables (CF) in protecting humans against cancer caused by chemically induced tumor formation.

According to the dietary information,

* CF and their constituents showed the effect on enzymes involved in the metabolism of DNA-reactive carcinogens.

* In vitro models, sulforaphane, a bioactive compound found in CF exerted antigenotoxic effects on metabolically competent cell lines.

* Furthermore, Brassica juices induced the production of glutathione-S-transferases (GST) and cytochrome P-450 1A2 in human hepatoma cells (HepG2) against the genotoxic effects of B(a)P and other carcinogens.

* Moreover, brussels sprouts- and garden cress juices attenuated IQ-induced DNA-damage and preneoplastic lesions in the colon and liver of rats.

* Most importantly, CF affects drug metabolism in humans and consumption of red cabbage led to changes in the pattern of meat-derived urinary mutagenicity.

Taken altogether, cruciferous vegetables may be considered functional foods for the protection of the cells against genotoxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of cruciferous vegetables and their constituents on drug-metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens by Steinkellner H1, Rabot S, Freywald C, Nobis E, Scharf G, Chabicovsky M, Knasmüller S, Kassie F. (PubMed)
 b(2) Chapter 18 - Genotoxicity and Cancer by Shareen H.Doak, Ying Liu, and ChunyingChen. (Science Direct)

Omega-3 Fatty Acids Improve Oral Mucositis and Body Weight Loss in Chemoradiotherapy Patients with Head and Neck Cancer

By Kyle J. Norton


Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

Head and neck cancer is a group of cancers found in the mouth, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer, at the early stage, start by the cell growth irregularly and disorderly on the surface of the inner lining in the head and neck.

At the advanced stage, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.

At this stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

Most common head and neck cancer metastases are secondary skin cancer.

The exact causes of head and neck cancer are unknown. Researchers cannot explain why people with similar health conditions and the same risk factors, are susceptible to the onset of the disease, while others do not.

Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.

 mitted virus.

According to the statistics, head and neck cancer accounts only for about 4% of all cancers in the US. In 2019, an estimated 65,410 people (48,000 men and 17,410 women) were fund to develop head and neck cancer. 

Most people diagnosed with head and neck cancer are older than 50.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effect of a nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®) on body weight loss, oral mucositis in patients with head and neck cancer.

The study included 17 patients with oropharyngeal and hypopharyngeal cancer who were treated with concomitant cisplatin and 70 Gy of radiotherapy with or without 2 packs of Prosure®per day during chemoradiotherapy.

According to the final results,

* The reduction in body weight was significantly improved compared with that in the historical control group that did not receive Prosure®(7.3% vs 10.3%, p<0.01),

* The rate of Grade 3-4 oral mucositis was significantly reduced for the patient groups that received Prosure®(CTCAE v3.0 GradeB3; 24% vs 58%, p<0.05).

Most importantly, the completion rate of chemoradiotherapy was not significantly different between both groups(77% vs 60%, NS).

Based on the evidence, researchers said, "A nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®)had effects on oral mucositis and body weight loss in head and neck cancer patients treated with chemoradiotherapy".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of breast cancer by reducing the breast density, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [A Nutritional Supplement with a High Blend Ratio of ω-3 Fatty Acids(Prosure®) Reduces Severe Oral Mucositis and Body Weight Loss for Head and Neck Cancer Patients Treated with Chemoradiotherapy].[Article in Japanese] by Mizumachi T1, Kano S, Homma A, Akazawa M, Hasegawa C, Shiroishi Y, Okamoto C, Kumagai S, Nishimura M, Takasaki H, Takeda H, Yasuda K, Minatogawa H, Dekura Y, Onimaru R, Shirato H, Fukuda S. (PubMed)
(2) A randomized clinical trial with two doses of a omega 3 fatty acids oral and arginine enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients by de Luis DA1, Izaola O, Cuellar L, Terroba MC, de la Fuente B, Cabezas G. (PubMed)

Tocopherols Inhibits the Onset of Colon Cancer in Vitro

By Kyle J. Norton

The colon also is known as the large bowel or large intestine, formed parts of the digestive system in our body.

The colon consists of four parts: descending colon, ascending colon, transverse colon, and sigmoid colon.

The main functions of the colon are to reabsorb fluids and process waste products from the body and prepare for its elimination.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. The stage of colon cancer is depended on how far the alternated cells have spread in the colon.

Patients with the early stage of colon cancer, may not experience any symptoms. But as the tumor spread and expanse, it may suppress the nearby tissue and nerve, causing symptoms of locally severe pain and discomforts.

Although there are many risk factors associated with the early onset of colon cancer, a poor diet high in saturated fat and trans fat, red meat and processed foods have been found to play a major role in the development and recurrence of colon cancer in the Western world.

According to the statistic by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The causes of colon cancer are unknown but certain risk factors, such as genetic preposition and chronic inflammation induced by colonic diseases are associated with the onset of the disease.

According to the statistics provided by the Canadian Cancer Society, In Canada, the 5-year net survival for colorectal cancer is 65%.

In other words, out of 100 people diagnosed with colon cancer, 65% of people will survive for at least 5 years after their diagnosis.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of co-treatment of γ-tocopherol and 5-FU in enhancing the efficacy of chemotherapy against HT-29 colon cancer cells.

According to the analysis,
* The IC50 values for 5-FU and γ-tocopherol were 21.8  ± 2.5 and 14.4 ± 2.6 μM, respectively, and also this combination therapeutic increased the percentage of apoptotic cells from 35% ± 2% to 40% ±  4% (P  <  .05).
* Incubation HT-29 colon cells with combined concentrations of two drugs also caused significant accumulation of cells in the subGsubG1 phase.

After talking about other factors into account, researchers said, "Our results presented the combination therapy with 5-FU and γ-tocopherol as a novel therapeutic approach, which can enhance the efficacy of chemotherapy".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Adjuvant therapy with γ-tocopherol-induce apoptosis in HT-29 colon cancer via cyclin-dependent cell cycle arrest mechanism by Bazzaz R1, Bijanpour H2, Pirouzpanah SMB2, Yaghmaei P1, Rashtchizadeh N. (PubMed)

Herbal Angelica Processes Anti Liver Cancer Activity in Vivo

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.
The liver organ is one of the organs with a lack of nerve tissues, therefore liver cancer does not induce pain until the later stage.

Cancer is a class of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

A primary tumor or original tumor is a tumor that is at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance of the body and alter the metabolic pathways, leading to disordered and violent cellular behavior.

Liver cancer is a medical condition characterized by cell growth irregularly and uncontrollably in liver tissue.

At the late stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissues.

According to statistics, approximately, 40000 adults in the United States will be diagnosed with primary liver cancer every year.

The disease also causes the annual death of 17,000 men and 8,000 women.

The 5-year survival rate of people who are diagnosed with liver cancer is 18%.

However, the 5 years of early diagnosis survival rate is 31%.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.

Birth defects, alcohol abuse, and chronic liver infection are most causes of liver cancer, diabetes and hemochromatosis also are associated with increased risk of chronic disease.

The most common risk factor of liver cancer is associated with hepatitis viral infection. People with chronic infection with HBV or HCV are found in the high percentage of patients with liver cancer.
The most common symptoms of liver cancer include jaundice, abdominal pain unexplained weight loss, an enlarged liver, fatigue,.... and back pain.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding the natural remedy for the p[revention and treatment of malignant tumor, scientists investigated the effects of Angelica Sinensis polysaccharide (ASP), a plant polysaccharide on liver cancer.

More precisely, Angelica Sinensis polysaccharide (ASP) was modified with a hydrophobic group (deoxycholic acid) to fabricate amphiphilic conjugate (ASP-DOCA) for a better release into the tissues.
According to the results of the DOX loaded nanoparticles (DOX/ASP-DOCA NPs) on hepatoma-targeted delivery of therapeutic drug doxorubicin (DOX), DOX/ASP-DOCA NPs induced a higher anti-proliferation effect than DOX-loaded dextran derivative DOX/DEX-DOCA NPs.

Furthermore, DOX/ASP-DOCA NPs showed higher inhibition on the growth of HepG2 multicellular spheroids (MCs) than DOX/DEX-DOCA NPs.

Moreover, In vivo, ASP-DOCA NPs specifically targeted HepG2 tumors via ASGPR, improved the accumulation of DOX/ASP-DOCA NPs in tumors and generated superior antitumor activity compared with free DOX and DOX/DEX-DOCA NPs.

Collectively, researchers said, " amphiphilic conjugate (ASP-DOCA) NPs possess potential applications in drug delivery systems targeting liver cancer".

Taken altogether, Herbal Angelica processes anti-proliferative activity against cancer, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica Sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer by Zhang Y1, Cui Z1, Mei H2, Xu J2, Zhou T1, Cheng F1, Wang K. (PubMed).

Herbal Dandelion(Taraxacum officinale), the Potential Anti- Cancer Remedy

By Kyle J. Norton

Cancer is a class of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

However, at the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.

Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

According to statistics, in 2018, approximately over 1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.

Lung, colorectal, breast, and prostate cancer are accounted for about half of all cancer diagnoses and deaths.

About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of malignant tumors, scientists examined the Taraxacum officinale, for the synthesis of silver nanoparticles (TOL-AgNPs). AgNPs anticancer activity.

According to the tested differentiation, the synthesized AgNPs had higher antioxidant activity in comparison with commercial AgNPs against the bacterial infection in inducing the oxidative stress in the alternation of cell DNA and lipid and protein damage.

The nanoformulations with tetracycline showed better broad-spectrum efficiency to control phytopathogens and significant antioxidant potential in terms of ABTS (IC50 = 45.6 μg/mL), DPPH (IC50 = 56.1 μg/mL), and NO (IC50 = 55.2 μg/mL) free radical scavenging activity.

Moreover, The TOL-AgNPs showed high cytotoxic effect against human liver cancer cells (HepG2).

Based on the results, researchers suggest, "Dandelion-mediated AgNPs synthesis can represent a novel approach to develop effective .....anticancer drugs with a cheap and eco-friendly nature".

Taken altogether, Dandelion may be considered a remedy for the treatment of cancers, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens by Saratale RG1, Benelli G2,3, Kumar G4, Kim DS5, Saratale GD. (PubMed)

Common Fig or Fig (Ficus carica) Processes Anti-Inflammatory Activity

By Kyle J. Norton

Inflammation is a systematic immune response during the acute phase of infection.

Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nerves system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens before they can enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage.

The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

Chronic inflammation is a result of a prolonged period of inflammation that lasts for several months and even years caused by the inability of the immune system to kill off all harmful microorganisms during the acute phase of infection.

Chronic inflammation can also be caused by an autoimmune disorder in which the immune system continuously attacks normal and healthy tissue, by mistaking them for pathogens.

Most common types of inflammatory diseases are
* Asthma
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.

* Tuberculosis
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Commonly, the bacterium attacked the lung tissue but in some cases, it also can cause major damage to other parts of the body.

The disease is very contagious, as types of bacteria that cause TB can spread from person to person through microscopic droplets released into the air.

* Rheumatoid arthritis
Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

* Periodontitis
Periodontitis is a severe stage of gingivitis that damages the soft tissue and destroys the bone that supports your teeth, leading to teeth loosen or tooth loss.

Fig is a species of F. carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding a natural whole food for the treatment of inflammatory diseases, researchers examined the anti-inflammatory activity of  Common Fig or Fig (F. carica) leaves on various inflammatory conditions like painful or swollen piles, insect sting, and bites.

According to the chemical analysis, the anti-inflammatory and antioxidant activity of the leaves was associated with the chemical compound steroids and flavanoids, respectively.

Furthermore, the efficacy of the whole food leaves was also found to attributed to the capacity of free radical scavenging activity.

In other words, fig leaves reduce the oxidative stress in inducing symptoms that are stimulated by the production of pro-inflammatory cytokines.

However, researchers wrote, "Further work is also required to isolate and characterize the active constituents responsible for the anti-inflammatory activities".

Taken altogether, common fig or fig may be considered a remedy for the treatment of inflammatory symptoms,  pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory and antioxidant activity of Ficus carica Linn. leaves by Ali B1, Mujeeb M, Aeri V, Mir SR, Faiyazuddin M, Shakeel F. (PubMed)

Broccoli's Sulforaphane (SFN), the Natural Pulmonary Injury Protector

By Kyle J. Norton

The lungs are a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.

Lung diseases are a group of medical conditions that cause the reduced function of the lung inhaling oxygen to the blood and exhaling carbon dioxide from the blood.

Pulmonary diseases are a class of diseases associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.

Pulmonary injury protection is the process that protects the lung functioning against damage or injury.

Any part of the lung injury can reduce lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.

In smokers, the Vaping-associated pulmonary injury (VAPI) associated with an e-cigarette, or vaping, product use associated lung injury (EVALI), recently has been found to induce pulmonary injury.

The ATS journals in the study of the "Vaping-associated Pulmonary Illness (VAPI)" wrote, "To date, the CDC has reported an epidemic of “severe lung disease” caused by vaping. Patients have presented with a range of symptoms, including shortness of breath, fever, cough, vomiting, diarrhea, headache, dizziness and chest pain following the use of vaping devices".

And, "As of September 16th 2019, the CDC has confirmed six deaths attributed to VAPI, and is evaluating over 350 cases.".

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find natural food for the prevention of pulmonary injury protection, researchers examined the effects of Sulforaphane (SFN) and standardized broccoli sprout extract diet (SBE) on pre-activation of Nrf2-ARE signaling protects lungs from an oxidant-induced acute injury.

According to the results of wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2-/-) mice given SFN orally or as standardized broccoli sprout extract diet (SBE) before hyperoxia or air exposure-induced pulmonary injury and oxidation Indice, SFN or SBE in Nrf2+/+ mice but not in Nrf2-/- mice showed a strong activity in protecting the lung against the lung oxidative stress.

Furthermore, SFN upregulated a large cluster of basal lung genes that are involved in mitochondrial oxidative phosphorylation, energy metabolism, and cardiovascular protection only in Nrf2+/+ mice.

Compared to the transcript abundance of the mitochondrial machinery genes which are remained significantly higher after hyperoxia exposure, SFN-treated Nrf2+/+ mice are lower than in SFN-treated Nrf2-/- mice.

In other words, the preactivation of antioxidant enzymes pathways Nrf2 plays an important role in enhancing the function of phytochemical SFN.

Moreover, nuclear factor-κB associated with the induction of pro-inflammatory cytokines expression also was showed that the efficacy of SFN also involved the molecule in transcriptome networks.

Collectively, researchers said, "SFN is suggested to be as a preventive intervention in a preclinical model of acute lung injury by linking mitochondria and Nrf2. Administration of SFN alleviated acute lung injury-like pathogenesis in an Nrf2-dependent manner".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention of pulmonary injury, pending to the confirmation of the larger sample size and multicenter human study.



Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice by Cho HY1, Miller-DeGraff L2, Blankenship-Paris T3, Wang X2, Bell DA2, Lih F4, Deterding L4, Panduri V4, Morgan DL5, Yamamoto M6, Reddy AJ7, Talalay P8, Kleeberger SR. (PubMed)
(2) Vaping-associated Pulmonary Illness (VAPI) by ATS Journals

Oleanolic Acid, The Promising Anti-Lung Cancer Phytochemical

By Kyle J. Norton

The lung formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.

Additionally, the lung also processes other ability in protecting our body against disease, including
* By balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body.

* By removing small blood clots the lung protects the body against the forming air embolisms.

* The airflow produced by the lung also help us to speak.

* The lung also protects the infection through the secretion of immunoglobulin A.

Any part of the lung injury can reduce lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancers is derived from epithelial cells. In the US, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.

Most common types of non-mall cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer. It usually grows and spreads methodically and predictably.
* Squamous-cell carcinoma often found in an outer area of the lung,
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma found in any part of the lung.

Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant that processes anti-cancer activity researchers examined the effect of triterpenoids, such as oleanolic acid (OA) and hederagenin on lung cancer.

According to the results of the analysis of the synthetic compound 17 OA/hederagenin-NO donor hybrids,

* The most potent compound, 13, significantly inhibited the proliferation of five tumor cell lines (IC50 4.6-5.2 μM), while hederagenin inhibited the growth of only A549 tumor cells (IC50 > 10 μM).

* The compounds 13 showed stronger inhibitory effects on EGFR-LTC kinase activity (IC50 0.01 μM) that prevents autophagic cell death than hederagenin (IC50 > 20 μM) and inhibited the proliferation of gefitinib-resistant H1975 (IC50 8.1 μM) and osimertinib-resistant H1975-LTC (IC50 7.6 μM) non-small-cell lung cancer (NSCLC) cells.

* Moreover, compound 13 produced the most NO in H1975 tumor cells, which indicated that NO may play a synergistic role in the inhibition of lung cancer cells.

Collectively, researchers said, "compound 13, a novel hederagenin-NO donor hybrid with a different chemical structure from those of the current FDA-approved EGFR-targeted anti-NSCLC drugs".

Taken altogether, oleanolic acid may be considered a remedy for the prevention and treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer by Chen Z1, Huang KY2,3, Ling Y4, Goto M5, Duan HQ1, Tong XH1, Liu YL1, Cheng YY5, Morris-Natschke SL5, Yang PC6, Yang SL1, Lee KH. (PubMed)

Ursolic Acid, The Potential Cancer Immunotherapy

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved in the onset of cancer.
Cancer immunotherapy is a type of treatment used to treat cancer patients that involve or uses components of the immune system.

Depending on types of cancer immunotherapies, some may consist of antibodies that bind or inhibit the expression of proteins in the cancer cells.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of ursolic acid (UA), a potent triterpenoid compound found in plants and fruits with activities modulating key cell-signaling pathways in cancer.

According to the analysis of the development of UA-liposomes made by HPβCD assisted active loading,
* Compared to lipid suspensions of UA (Lipid-UA) with similar lipid composition, the novel process enabled the formation of UA-Ca crystalline structures inside the liposomes and therefore sustained release of UA in vivo.
* UA-liposomes were not generally toxic towards 4T1 triple-negative breast cancer cells, they could effectively modulate CD4+CD25+Foxp3+ in regulating T cells from 4T1 tumor-bearing mouse by inhibiting the inflammatory cytokines.

* In vivo, the administration of UA-liposomes at 10 mg/kg dose led to reduced numbers of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) residing in tumor tissues

Collectively, researchers said, "These changes signified the correction of the tumor mediated immune-suppressive microenvironment. The UA-liposomes treatment alone was already effective in deterring tumor growth. Such a formulation may be highly promising as an immunotherapy agent and be combined with chemotherapeutics or targeted drugs",

Taken altogether, Ursolic acid may be considered adjunct-immunotherapy. therapies in the treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Ursolic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy by Zhang N1, Liu S2, Shi S2, Chen Y2, Xu F2, Wei X2, Xu Y. (PubMed)

Beta-Sitosterol Protects the Kidney Against Acute Nephrotoxicity

By Kyle J. Norton


Kidneys are two bean-shaped organs located below the rib cage, one on each side of your spine with a function to filter out blood and remove waste through urinary secretion.

The kidney also plays a critical in maintaining the levels of fluids in the body, by removing extra fluids to make urine.

Furthermore, the kidney also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.

Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.

Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.

Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.

The disease is caused by a poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.

According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.

And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.

According to the information provided by the WHO, each year, around 1.7 million people are thought to die from acute kidney injury. Overall, therefore, an estimated 5–10 million people die annually from kidney disease.

Furthermore, in 2010, an estimated 2.3–7.1 million people with end-stage kidney disease died without access to chronic dialysis.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of kidney diseases, researchers elucidated the effects of plant sterol β-sitosterol on acute nephrotoxicity.

In vivo, the male albino Wistar rats were randomly grouped into four:
* Group 1 was vehicle control rats (0.1% carboxymethyl cellulose [CMC]);

* Group 2 was rats treated with N-diethylnitrosamine (DEN) (200 mg/kg body weight [bw] i.p. on the 15th day) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg BW i.p. on 30th and 32nd days);

* Group 3 was rats that received β-sitosterol (20 mg/kg BW in 0.1% CMC, p.o. for 32 days) 2 weeks prior to the exposure to the nephrotoxins; and

* Group 4 was rats that received β-sitosterol alone.

According to the experimental results that were terminated after the 24 h of the last dosage of Fe-NTA, and all the animals were sacrificed,

* DEN and Fe-NTA treated animals induced the elevated parameters of stress markers, reduced antioxidant and increased lipid peroxidation and inflammatory markers in the kidney.

* However, the β-sitosterol pretreated group restored all altered biochemical parameters back to near normal by upregulating the function of antioxidant enzyme protein Nrf2 expression.

Based on the findings, researchers said, "Administration of β-sitosterol to nephrotoxicity induced rats showed significant positive changes in biochemical parameters, histopathological and immunohistochemical observations, and up-regulation of Nrf2 gene expression".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of acute nephrotoxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats by Sharmila R, Sindhu G, Arockianathan PM. (PubMed)

Omega-3 Fatty Acids Process Anti Non Melanoma Cancer Activity in Vitro

By Kyle J. Norton

Skin, a large organ that forms the out layers of our body has serval layers of ectodermal tissue that protect the underlying muscles, bones, ligaments, and internal organs against foreign pathogenic invasion.

Skin cancer is a medical condition characterized by disordered and irregular cell growth in the skin.

Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.

Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which is the cell produced dark pigment for your skin. 

Approximately 120,000 new cases of melanoma in the US are diagnosed in a year. melanoma tends to spread along the skin in most of the cases, but also can grow down to the deeper layers of the skin. At the later stage, it can spread to distant parts of the body, including organs.

Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin. However, at the later stage, the cancer cells can travel through the circulation of blood and fluids to infect other healthy cells and tissue, leading to secondary metastasis.

The liver, lungs, bones, and brain are most often affected by melanoma metastases.

According to statistic, the risk of melanoma is largely depended on the race. The lifetime risk of getting melanoma is about 2.5% (1 in 40) for whites, 0.1% (1 in 1,000) for blacks, and 0.5% (1 in 200) for Hispanics.

The 5 years survival rate of melanoma is closed to 100% if the disease is diagnosed in the localized stages.

In the US, every year, approximately 96,480 new melanomas are diagnosed, leading to the death of 7,000 people.

In North America, most cases of melanoma are associated with UVB exposure, causing the alteration of the cell DNA.


Nonmelanoma skin cancer is a type of skin cancer involved in basal cell carcinoma and squamous cell carcinoma.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers examined the role of omega-3 FA in the prevention of non-melanoma skin cancer (NMSC).

According to the results of the analysis

* Dietary omega-3 FA dramatically reduces the plasma and cutaneous pro-inflammatory and immunosuppressive PGE(2) levels in vivo, compared to dietary omega-6 FA in the increase of prostaglandin E synthase type 2 (PGE(2)) level.

* Dietary omega-3 FA significantly reduces the inflammatory response and sustains, or enhances, the delayed-type hypersensitivity immune response in mice when compared to an equivalent dietary level of omega-6 FA.

* Supplementary omega-3 FA significantly increases the UVR-mediated erythema threshold in humans. 

Furthermore, supplementary omega-3 FA significantly reduces the level of pro-inflammatory and immunosuppressive PGE(2) levels in Ultraviolet B-irradiated human skin.

In other words, omega-3 FA showed a strong implication on the immune response in the induction of pro-inflammatory cytokines induced the risk of non-melanoma skin cancer (NMSC).

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of skin cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The potential of omega-3 fatty acids in the prevention of non-melanoma skin cancer by Black HS1, Rhodes LE. (PubMed)
(2) Potential Benefits of Omega-3 Fatty Acids in Non-Melanoma Skin Cancer by Black HS1, Rhodes LE. (PubMed)