Tocopherols Protect the Electrical Activity in the Brain Against Seizure

By Kyle J. Norton

Epilepsy is a condition of a neurological disorder caused by abnormal electrical activity in the brain inducing sudden recurrent episodes of sensory disturbance and convulsions.

Anticonvulsant is a function to control seizures (convulsions) or stop an ongoing series of seizures.

A seizure is a sudden, abnormal electrical disturbance in the brain. Epidemiological studies suggested seizures can change in behavior, movements or feelings, and in levels of consciousness.

The hormone melatonin is approved only for the treatment of jet-lag syndrome and some types of insomnia, clinical data also suggest that it is effective in the adjunctive therapy of osteoporosis, cataract, sepsis, neurodegenerative diseases, hypertension, and even cancer. 

 In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy. 

Its additional benefits include improved physical, emotional, cognitive, and social functions. On the other hand, melatonin has been shown to induce electroencephalographic abnormalities in patients with temporal lobe epilepsy and increase seizure activity in neurologically disabled children. 

The hormone showed very low toxicity in clinical practice, according to the study by the Department of Pathophysiology, Medical University, PL 20-090 Lublin, Jaczewskiego 8, Poland(22).

The most common symptoms of seizure, signs, and symptoms can range from mild to severe and vary depending on the type of seizure, according to the Mayo clinic, including
* Temporary confusion

* A staring spell

* Uncontrollable jerking movements of the arms and legs

* Loss of consciousness or awareness

* Cognitive or emotional symptoms, such as fear, anxiety or deja vu

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of epilepsy, researchers examined the
inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats.

According to the results of ascorbic acid (250 or 500 mg/kg, i.p.) and alpha-tocopherol (200 or 400 mg/kg, i.p.) on the behavior and brain lesions on seizures induced by pilocarpine (400 mg/kg, i.p., P400 model), Ascorbic acid or alpha-tocopherol injections prior to pilocarpine suppressed behavioral seizure episodes.

Furthermore, the antioxidant administration inhibited free radicals that cause brain damage induced by seizures.

In the P400 model, ascorbic acid and alpha-tocopherol significantly decreased cerebral damage percentage. 

More precisely, antioxidant compounds can exert neuroprotective effects associated with the inhibition of free radical production.

 Based on the results, researchers said, " These results highlighted the promising therapeutic potential of ascorbic acid and alpha-tocopherol in treatments for neurodegenerative diseases".

Taken altogether, tocopherols may be considered a supplement for prevention and treatment of seizure, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats by Tomé Ada R1, Ferreira PM, Freitas RM. (PubMed)
(2) The Effects of Hormone Melatonin (N-acetyl-5-methoxytryptamine) (3) by Kyle J. Norton