Herbal Angelica Inhibits the Acute Coronary Syndrome in Patient with Renal Deficiency

By Kyle J. Norton

The acute coronary syndrome is a medical emergency associated with a range of conditions caused by sudden, reduced blood flow to the heart, leading to heart muscle damage and brain apoptosis depending on the affected location.

The acute coronary syndrome is associated with the severity of buildup of plaque deposits in and on the walls of the coronary arteries.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

Arteries formed a part of blood vessels and circulatory system with function to deliver oxygen and nutrients to heart muscles.

Depending on the severity of the blockage, a complete blockage is life-threatening. Symptoms of acute coronary syndrome, chest pain or discomfort, pain or discomfort in one or both arms, the jaw, neck, back or stomach, shortness of breath, dizziness, and nausea.

If the chest pain is persistent with no sign of stopping, please call 911 immediately.

The most common treatment of acute coronary syndrome is medicine to reopen the artery. However, in severe cases, angioplasty (a inflate a small balloon) may be necessary.

Traditionally, over many decades, patients with acute coronary syndrome are likely to be treated by oxygen therapy.

Dr. Pankaj Garg in the examing the effects of oxygen therapy on patients with acute coronary syndrome wrote, " However, more recently, there have been many reports of harmful effects of high-flow oxygen in ACS patients where the patient might not be hypoxic".

Anf "High flow oxygen has been shown previously to reduce cardiac output,2 attributes to arterial vasoconstriction3–5 and also to increase systemic vascular resistance.6 More recently, two systematic reviews suggest that the routine use of high-flow oxygen in uncomplicated myocardial infarction may result in greater infarct size and possibly increase the risk of mortality".

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound that inhibits acute coronary syndrome, researchers examined the neuroprotective effects of Chinese herbal medicines in the cardiovascular outcome among patients with acute coronary syndrome (ACS) and renal insufficiency after the percutaneous coronary intervention (PCI).

The study included population consisted of 215 subjects in the control group who were treated with western medicine standard therapy, and 211 subjects in the treatment group who were treated with Chinese herbal medicines (Fufang Chuanxiong Capsule and Xinyue Capsule) for 6 months.

Participants are from the 5C trial with post-PCI patients suffered from ACS with mild-to-moderate renal insufficiency (30 mL•min-1•1.73 m-2 < estimated glomerular filtration rate≤89 mL•min-1•1.73 m-2).

According to the endpoints including the composite of cardiac death, nonfatal recurrent myocardial infarction, and ischemia-driven revascularization assays, after one year of following up of 2 groups

*There were 16 cases of the primary endpoint in the control group and 6 cases of the primary endpoint in the treatment group with an absolute risk reduction ARR=0.046. elative risk RR= 0.38.

* There were 15 cases of secondary endpoint in the control group and 5 cases of secondary endpoint in the treatment with ARR= 0.041 and RR=0.34

In other words, the treatment of Chinese and Western medicines showed a strong effect in reducing the risk of the acute coronary syndrome in patients with renal deficiency.

However, The eGFR levels associated with the renal functioning in the treatment group were significantly higher, compared to the higher levels in the control group.

Based on the findings, researchers said, "Chinese herbal medicines plus western medicine standard therapy improved clinical outcomes in patients with ACS and mild-to-moderate renal insufficiency. Additionally, this study also demonstrated Chinese herbal medicines were useful in deferring the decline of renal function".

Taken altogether, herbal Angelica in combination with other herbal medicines that may be considered a remedy for the treatment of acute coronary syndrome, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention by Zhang DW1, Wang SL2, Wang PL1, Du JP1, Gao ZY1, Wang CL1, Xu H1, Shi DZ. (PubMed)
(2) Oxygen therapy in acute coronary syndrome: current NICE recommendations by Pankaj Garg. (PMC)