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Monday, 6 January 2020

Dandelion (Taraxacum officinale) Reduces the Side Effect of Chemo Drug Induce-Anorexia

By Kyle J. Norton

Eating Disorders are a group of abnormal eating habits associated with a person's preoccupation weight, involving either insufficient or excessive food intake.

Eating disorders can be classified into
* Anorexia nervosa is a type of eating disorder usually develop in the teen years and affects over 90% of females, because of excessive food restriction and irrational fear to become fat due to the wrongly influenced media as attractiveness is equated to thinness.

* Bulimia nervosa
Bulimia nervosa is a medical condition of consuming a large amount of food in a short amount of time or one setting (binge eating), followed by self-induced vomiting, and taking a laxative or diuretic and/or excessive exercise, etc. to compensate for the binge. Bulimia Nervosa also affects almost 90% of females.

* Binge eating disorder
Binge eating disorder is a medical condition of compulsive eating of huge amounts of food while feeling out of control and powerless to stop. It is a common eating disorder in the United States affecting 3.5% of females and 2% of males.

Most common symptoms of Anorexia nervosa are
* Weight loss, sometimes severe as a result of malnutrition.

* Refusal to maintain a normal or minimally above normal body mass index for their age and Dieting despite being thin or dangerously underweight

* Intense fear of gaining weight and primary or secondary amenorrhea

In the study Eating disorders. A review and update by Haller E. at the University of California indicated Anorexia nervosa is diagnosed when a person refuses to maintain his or her body weight over a minimally normal weight for age and height, such as 15% below that expected, has an intense fear of gaining weight, has a disturbed body image, and, in women, has primary or secondary amenorrhea(2).

* Obsession with calories and fat content of food and try to avoid eating altogether. They deny hunger and will usually avoid eating around others as well as avoiding situations where food might be present(3).

* Disturbance to body image the person hold of him/herself
In the study of Eating disorders. A review and update, Dr. E Haller indicated that anorexia Nervosa is diagnosed when a person refuses to maintain his or her body weight over a minimally normal weight for age and height, such as 15% below that expected, has an intense fear of gaining weight, has a disturbed body image, and, in women, has primary or secondary amenorrhea(4).

*Abdominal pain and distention
Anorexia nervosa is also associated with abdominal and with a sensation of elevated abdominal pressure.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of eating disorders in chemotherapy patients, scientists examined the anti-anorexia of herbal mixtures extracts LCBP‑Anocure‑16001‑3 (LA16001, LA16002, LA16003), composed of Atractylodes japonica, Angelica Gigas, Astragalus membranaceus, Lonicera japonica Thunb., Taraxacum Platycerium H. Dahlstedt and Prunella vulgaris var. Asiatica (Nakai) Hara.

In a cisplatin‑induced anorexia mouse model, treatment with LA16001 prevents body weight loss. However, all three extracts were demonstrated to improve food intake.

LA16001showed to altered expression levels of ghrelin, leptin, and interleukin‑6 associated with infection.

In other words, LA16001 modulated the interleukin‑6 activation of phosphring the caorylation of Janus kinase 1 and signal transducer and activator of transcription 3 during the course of infection induce-inflammation observed by the increase of the number of white blood cells and neutrophils. 

Based on the findings, researchers said, " the herbal formula LA16001 may be able to prevent chemotherapy‑induced anorexia and may have potential as a novel therapeutic strategy for the adjuvant treatment of patients with cancer".

Taken altogether, dandelion may be used to enhance and prevent side effect in a combination with chemo drugs in chemotherapy, pending to the confirmation of the larger sample size and multicenter human study. 



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia by Woo SM1, Lee KM2, Lee GR2, Park JY2, Lee HJ2, Bahn HJ2, Yoon HS2, Kim JY2, Shin YC3, Cho SG4, Ko SG. (PubMed)
(2) Eating Disorders: Anorexia nervosa - Symptoms and Signs by Kyle J. Norton


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