Phytochemical Beta-Sitosterol, the Anti-Cancer Potential Antioxidant

By Kyle J. Norton

Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.

At the advanced stage, cancer not only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also induce specific symptoms, such as localized bleeding and pain, depending on the location of the cancer.

Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.

Some cancers can be slow-growth, including prostate and colon cancer. Primary cancer at stages 0 and 1 may not induce any symptoms. However, at the later stage, a larger size tumor can induce specific symptoms depending on the affected organ accompanied by some general symptoms found in all types of cancer.

According to the statistic provided by the American Cancer Society, in the US in 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results from cancer.

Furthermore, in the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.

There are many prevalent factors associated with cancer onset, including an increase in age, excessive alcohol consumption, exposure to chemical toxins and sunlight, and infectious pathogens.

The 5 years survival rate is totally depending on the stage of cancer diagnosed. The early diagnosed stage has the highest survival rate compared to other later stages.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of malignant tumors, researchers examined the effect of beta-sitosterol (BS), a plant-derived nutrient on several types of cancer, including breast cancer, prostate cancer, and colon cancer, lung cancer, stomach cancer, ovarian cancer, and leukemia.

According to some studies, BS interferes with multiple cell signaling pathways, associated with cancer progression, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis, and inflammation. 

BS which is delivered directly to the cancer cells is relatively less potent, compared to BS delivery through liposomes. 

In other words, in order to offset the lower efficacy of BS, designing BS delivery for "cancer cell-specific" therapy is necessary.

Taken altogether, beta-Sitosterol may be considered a functional food for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
Cancer
(1) Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer by Bin Sayeed MS1, Ameen SS. (PubMed)