Plant-Based 3,3'-Diindolylmethane (DIM), the Best for the Treatment of Radiation Induced Intestinal Injury in Vivo

By Kyle J. Norton


Intestinal injury of small bowel, colon, or rectum can be due to blunt or penetrating trauma, and irradiation.

Intestinal injury can be minor which can be healed by its own or devascularization for blunt injuries and small perforations which may require surgery.

Most common symptoms of intestinal injury are totally depending on the severity of the damage, including abdominal tenderness or distention, mild, moderate or severe abdominal pain,  forceful bowel movements, the urge to have a bowel movement.

Patients may also experience symptoms of blood in the stool and mental confusion.

If you have some of the aforementioned symptoms, please see your doctor immediately.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding a natural compound for the treatment of intestinal injury, researchers examined 3,3'-Diindolylmethane (DIM), a potent antioxidant agent in the amelioration of hematopoietic injury in a murine model of total body radiation injury.

In abdominal irradiation-induced intestinal injury in mice, administration of DIM ameliorated crypt-villus structural and functional injury of the small intestine.

DIM also protected the mice against whole abdominal irradiation (WAI)-induced lethality and weight loss. 

Furthermore, MIC was found to promote the small intestine repair following WAI exposure.

MIC protected the intestinal cell against apoptosis caused by the injection of WAI by stimulating the production of proteins which protect the cells against oxidative damage triggered by injury and inflammation. 

In other words, DIM protected human intestinal epithelial cell-6 (HIEC-6) against ionizing radiation, leading to increase cell vitality by protecting the cell DNA against damage caused by radiation.

The efficacy of the protective activity in the depth analysis was found to associate with the reduction of reactive oxygen species (ROS) levels and promotion of the production of antioxidant enzymatic in tested HIEC-6 cells.

Based on the results, researchers suggested DIM restores the WAI-shifted gut bacteria composition in mice in the exhibition of intestinal injury.

Dr. the lead scientists after taking other factors into accounts said, "the beneficial properties of DIM mitigate intestinal radiation injury, which provides a novel strategy for improving the therapeutic effects of irradiation-induced intestinal injury".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection and treatment of intestinal injury, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Amelioration of whole abdominal irradiation-induced intestinal injury in mice with 3,3'-Diindolylmethane (DIM) by Lu L1, Jiang M2, Zhu C2, He J2, Fan S. (PubMed)