Thyme Honey, the Potential Anti Endometrial Cancer Functional Food

By Kyle J. Norton

Honey may have a significant effect on reducing risk and treatment of endometrial cancer, some scientists suggested.

Endometrial cancer is a chronic condition characterized by the irregular cell in the tissue of the endometrium.

Most cases of endometrial cancer start on the cells in the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.

Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.

The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age,  more years of menstruation, never been pregnant, obesity and use of hormone therapy are some the major prevalent risk factors associated with endometrial cancer.

Some researchers indicated that hormone change in the women body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.

Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".

"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".

These result clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the diseases. However, the study of PCOs in the endometrial cancer risk should also be taken into accounts of obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.

In the association of PCOs and endometrial cancer mortality, the doctor team indicated, there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome. 

The study once again reaffirms the link of the estrogen therapy used in menopause women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body is the major cause of endometrial cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined the honey influence the oestrogenic activity.

The chemical composition and the potential of Greek honey extracts (thyme, pine and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.

Compared to other honey, thyme honey processes a highest total phenolics, phenolic acids, and hydroxymethylfurfural.

Thyme honey inhibited the expression of Ishikawa by reducing the cancer cells viability.

Moreover, application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting the cancer cell proliferation, inducing apoptosis and cell cycle arrest.

Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.

The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven  to inhibit cancer-related pathways and processes

These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, though it's agonists/antagonists properties.

Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, " honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".

Taken altogether, Thyme honey processed major bioactive compounds  polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapy for the treatment of endometrial cancer without inducing any side effects

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts  (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)