By Kyle J. Norton
Decreased hormonal secretions due to aging stimulates the production of
the enzyme 5-alpha
reductase to converse testosterone to
gihydro-testosterones DHT, affecting hair to grow back thinner or not
grown back at all. DHT shrinks the follicles, causing hair thins and
hair receded at
the forehead, crown and temple for men and thins over the entire scalp
for women. Herbal treatment for hair loss has existed throughout human
history, but epidemiological studies, linking herbs effectiveness in
treating hair loss have produced inconsistent results.
Androgenetic alopecia
Androgenetic alopecia is a common hair loss in men and women. In men, it
causes baldness patterns, receding at the forehead. In women, the hair
becomes thinner all over the head, and the hairline does not recede.
1. Thujae occidentalis
Thujae occidentalis is an evergreen coniferous tree, belonging to the
cypress family, native to the United States and the southeast of Canada.
the herb has been used in folk medicine in treating warts, ringworm and
thrush.
In HEK 293 cell line derived from human embryonic kidney cells grown in
tissue culture, with expressing human 5alpha-reductase (type 2), Thujae
occidentalis semen (TOS) extract in comparison with gamma-linolenic acid
and finasteride (a synthetic drug used to be for the treatment of benign prostatic hyperplasia), topically applied to fuzzy rat and androchronogenetic alopecia
(AGA) mouse, showed effectiveness in treating male pattern baldness
by dictating androgen conversion with higher inhibition activity of
5alpha-reductase type 2 than that of gamma-linolenic acid, but lower
than that of
finasteride. These result indicated that the extract may be a potent
agent for treating male baldness(1).
2. Cuscuta reflexa Roxb(Dodder)
Cuscuta reflexa Roxb is a Perennial tree, belonging to the family
Cuscutaceae, native to the Eastern Asia. Petroleum ether extract of C.
reflexa, in the experiment used as a topical application, showed the
Inhibition of 5alpha-reductase activity, exhibited hair growth-promoting activity, by blocking conversion of testosterone to dihydrotestosterone which causes hair receded,(2).
3. Citrullus colocynthis Schrad
Citrullus colocynthis is a desert viny plant native to the Mediterranean
Basin and Asia. The herb has been used in folk medicine for treatments
of cancer, carcinoma, endothelioma, leukemia, corns, tumors, etc. In
androgen-induced alopecia mice, the petroleum ether extract of C. colocynthis showed an effectiveness in enhancing follicular density, exhibited hair growth-promoting activity in anagenic phase than the standard finasteride(3).
4. Eclipta alba(false daisy)
Eclipta alba is a species of E. prostrata ,
belonging to the family Asteraceae, native to India, China, Thailand,
and Brazil. The herb has been used in folk medicine for treatments of
combating swelling, inflammation, skin conditions, etc.. Petroleum
ether and ethanol extract of E. alba Hassk in comparison with minoxidil
2% in rat study, exhibit hair growth pattern better than the positive
control minoxidil 2% with significantly reduced time for complete hair growth.(4)
5. Garlic
Garlic (Allium sativum)
is a species in the onion genus, belonging to family Amaryllidaceae,
native to central Asia. It has been used popularly in traditional and
Chinese medicine in treating common cold and flu to the Plague, blood
pressure cholesterol levels, natural antibiotic, etc., Experiment of
garlic gel in promoting hair growth showed a positive response in
enhancing the application of topical betamethasone valerate(5).
6. Onion
The onion is a plants in the genus Allium,
belongs to the family Alliaceae, a close relation of garlic. It It is
often called the "king of vegetables" because of its pungent taste and
found in a large number of recipes and preparations spanning almost the
totality of the world's cultures. Depending on the variety, an onion
can be sharp, spicy, tangy, pungent, mild or sweet. Topical crude onion
juice in the study against hair loss, exhibited Re-growth of terminal
coarse hairs after two weeks of application, in significantly higher
among males compared to females, after 4 weeks(6).
7. Polygonum multiflorum
He Shou wu is
also known as Chinese Knotweed, genus Fallopia, belonging to
Polygonaceae, native to central and southern China. It has been used in
traditional Chinese medicine in treating hyperlipemia, neurasthenia,
split personality, premature white hair, nerve injuries, skin wind rash,
constipation, etc.. Ethanol extract from Polygonum multiflorum
roots in the experiment using dermal papilla cells (DPCs), showed
to increase the proliferation of DPCs which plays an impotant role
in enhancing hair growth and hair-fiber
length significantly(7). In topically applied to the shaved dorsal skin
of telogenic C57BL6/N mice, the extract stimulated hair growth by inducing anagen phase and the number and the size of hair follicles(8).
8. Platycladus
Thuja orientalis is a evergreen coniferous tree
belonging to the family Cupressaceae, native to northwestern China.
The herbs has been used in traditional medicine in treating baldness and
hair loss in East Asia. T. orientalis
extract, in the experiment of topically applied to the shaved dorsal
skin of telogenic C57BL/6 N mice, induced an earlier anagen phase and
prolonged the mature anagen phase, reduced earlier induction of
β-catenin and Shh proteins in hair follicles. These result indicated that Thuja orientalis may be beneficiary as a potential hair growth-promoting agent.(9).
9. Asiasari radix(Chinese wild ginger root)
Asiasari radix has been used in Asian traditionally medicine for treating hair loss in to stimulate hair growth. In female C57BL/6 and C3H mice, Topical application onto the backs of Asiasari radix extract showed an effectiveness in promoting hair
growth and increased protein synthesis in vibrissae follicle cultures
and the proliferation of both HaCaT and human DP cells in vitro.(10)
10. Sophora flavescens
Sophora flavescens is a species of genus
Sophora, belonging to family Fabaceae. The herb has been used in
traditional medicine for treatments of viral hepatitis, enteritis,
cancer, viral myocarditis, gastrointestinal hemorrhage etc. In the
experiment of topical application of Sophora flavescens extract in C57BL/6 mice, enhanced on hair growth may be mediated through the regulation of growth factors in dermal papilla cells and inhibited the type II 5alpha-reductase activity(11).
11. Crinum asiaticum
Crinum asiaticum is a genus of
Crimum, belonging to the family Amaryllidaceae, native to Jeju Island,
Korea. The herb has been used in habal medicne for treatments of injury
and inflamed joints, swellings, swollen joints, lumbago, pains and in
cases of headache, fever, etc. Topical application of the EtOH extract
of C. asiaticum onto the back of C57BL/6, increased the proliferation
of immortalized vibrissa dermal papilla cells, cell nuclear antigen
(PCNA) in the bulb region and the hair-fiber lengths of vibrissa(12). Norgalanthamine, a chemical constituent of Crinum asiaticum, also induced anagen progression of the hair shaft, increased the proliferation of immortalized vibrissa dermal papilla cells(16)
12. Ishige sinicola
Ishige sinicola is a genus of
brown algae (class Phaeophyceae), belonging to the family Ishigeaceae
native to native to Jeju Island, Korea. Topical application of I.
sinicola extract onto the back of C57BL/6 mice inhibit anagen progression of the hair
shaft and activity of the activity of 5α-reductase, increased cell
proliferation vibrissa dermal papilla cells (DPCs), downregulated
p27kip1 in stopping or slowing down the cell division cycle(13).
13. Acenthopanax koreanum
Acanthopanax koreanum Nakai
(Araliaceae), a well-known herbal medicine in Jeju Island, Korea, has
been used as a tonic agent in treating stress-related states(14). In the
experiment of immortalized rat vibrissa dermal papilla cells treated
with extract of A. koreanum leaves, showed an enhacement of the proliferation of dermal papilla cells, of the hair-fiber
lengths of the vibrissa follicles by increasing the nuclear β-catenin
level, and up-regulation of cyclin D1, cyclin E (regulating cell cycle
progression) and CDK2(Cells decide at the end of mitosis to either start
the next cell cycle and downregulation of the expression of p27(kip1)(Cyclin-dependent kinase inhibitor) in the dermal papilla cells(15).
14. Schisandra nigra
Schisandra nigra, a plant
native to Jeju Island, South Korea. The herb has been used in
traditional medicine for liver protection and treatments of nervous,
respiratory system. Topical application of the EtOH extract of S. nigra onto the back of C57BL/6 mice nigra, exhibited the increased hair-fiber lengths of the vibrissa follicles, induced anagen progression of the hair
shaft and increased both the expression of proliferating cell nuclear
antigen (PCNA) in the bulb matrix region and the proliferation of
immortalized vibrissa dermal papilla cells(17).
The enhancement of herbal medicine for treatments of hair loss, linking to inhibit anagen progression of the hair
shaft and activity of 5α-reductase, increase proliferation vibrissa dermal papilla cells with little or no side
effects has produced a promising result. Somedays, they may be
considered as approval prominent treatments, in improving the
appearance as well as quality of life by reducing the psychological
stress with affordable cost. Once again, please consult you doctor or
related field specialist before applying,
STOP HAIR LOSS - PERMANENTLY
Fill in Bald Spots, Stop Thinning Hair And
Restore Receding Hair Lines, Naturally
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References
(1) The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse by Park WS, Lee CH, Lee BG, Chang IS.(PubMed)
(2) Effect of Cuscuta reflexa Roxb on androgen-induced alopecia by Pandit S, Chauhan NS, Dixit VK.(PubMed)
(3) Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia by Dhanotia R, Chauhan NS, Saraf DK, Dixit VK.(PubMed)
(4) Hair growth promoting activity of Eclipta alba in male albino rats by Roy RK, Thakur M, Dixit VK.(PubMed)
(5) Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study by Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R.(PubMed)
(6) Onion juice (Allium cepa L.), a new topical treatment for alopecia areata by Sharquie KE, Al-Obaidi HK.(PubMed)
(7) Promotion effect of constituents from the root of Polygonum multiflorum on hair growth by Sun YN, Cui L, Li W, Yan XT, Yang SY, Kang JI, Kang HK, Kim YH.(PubMed)
(8) Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice by Park HJ, Zhang N, Park DK.(PubMed)
(9) Hair growth-promoting activity of hot water extract of Thuja orientalis by Zhang NN, Park DK, Park HJ.(PubMed)
(10) The hair growth promoting effect of
Asiasari radix extract and its molecular regulation. ho SS, Park SJ,
Hwang SL, Lee MH, Kim CD, Lee IH, Chang SY, Rang MJ.(PubMed)
(11) The hair growth promoting effect of Sophora flavescens extract and its molecular regulation by Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK.(PubMed)
(12) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed).
(13) The promoting effect of Ishige sinicola on hair growth by Kang JI, Kim EJ, Kim MK, Jeon YJ, Kang SM, Koh YS, Yoo ES, Kang HK.(PubMed)
(14) The effects of a standardized Acanthopanax koreanum extract
on stress-induced behavioral alterations in mice by Jung JM, Park SJ,
Lee YW, Lee HE, Hong SI, Lew JH, Hong E, Shim JS, Cheong JH, Ryu JH.(PubMed)
(15)Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth by Kim SC, Kang JI, Park DB, Lee YK, Hyun JW, Koh YS, Yoo ES, Kim JA, Kim YH, Kang HK.(PubMed)
(16) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed)
(17) Promotion effect of Schisandra nigra on the growth of hair by Kang JI, Kim SC, Hyun JH, Kang JH, Park DB, Lee YJ, Yoo ES, Kang HK.(PubMed)
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