Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells
in the colon, rectum, or vermiform appendix. Bowl is divided in 2
parts, the first part of the bowel, the small bowl, is involved with the
digestion and absorption of food. The 2nd part, the large bowel which
consist the the colon and rectum, is involved in absorption of water
from the small bowel contents and broken down of certain materials in
the feces into substances of which some of them to be re absorbed and
reused by the body. Bowel cancer is relatively very common and slowly
growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
The effects
Inositol hexaphosphate (IP6), or phytic acid is best known as a natural fighter against cancers. In the study on HT-29 Colorectal Cancer
Cells, the phytochemical exerted a strong evidence for the induction of
apoptotic cell death, as a result of up-regulation of Bax and
down-regulation of Bcl-xl in favor of apoptosis. Other in the study of
the expression changes of β-catenin and cyclooxygenase-2 (COX-2) and
cell proliferation in the adenoma-carcinoma sequence after treatment
with rice bran PA by immunocytochemistry also showed the similar result
as phytic acid lowering the proliferating index as compared to
azoxymethane (AOM) alone (p<0.05). A significant positive correlation
(p=0.01) was noted between COX-2 expression and proliferation.
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References
(1) Pro-Apoptotic Effect of Rice Bran Inositol Hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells by Shafie NH, Esa NM, Ithnin H, Saad N, Pandurangan AK.(PubMed)
(2) Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA) by Saad N, Esa NM, Ithnin H.(PubMed)
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