Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
Diabetes is defined as a condition caused by
insufficient insulin entering the bloodstream to regulate the glucose.
It is either caused by cells in pancreas dying off or receptor sites
clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
The benefits
Administration of piperine isolated from
the fruits of Piper nigrum crude extract diabestes induced in albino
mice using alloxan, showed the crude extract exhibit its anti-diabetic
effect inducing a significant blood glucose lowering at dose of 20
mg/kg on day 14. In other alloxan-induced diabetic models study, piperine
(10 mg/kg) significantly increased the dose-dependent
anti-hyperglycemic activity of nateglinide(a drug for the treatment of
type 2 diabetes), leading to synergistic anti-hyperglycemic activity of
the diabetic medicine. In diabetes-induced oxidative stress in 30-day streptozotocin-induced diabetic Sprague-Dawley rats, piperine
treatment (10 mg/kg/day, intraperitoneally for 14 days) reversed the
diabetic effects on oxidized glutathione concentration in brain, on
renal glutathione peroxidase and superoxide dismutase activities, and on
cardiac glutathione reductase activity and lipid peroxidation.
Ovarian Cysts And PCOS Elimination
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Reference
(1) Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice by Atal S, Agrawal RP, Vyas S, Phadnis P, Rai N.(PubMed)
(2) Effect of piperine on
antihyperglycemic activity and pharmacokinetic profile of nateglinide by
Sama V, Nadipelli M, Yenumula P, Bommineni MR, Mullangi R.(PubMed)
(3) Effects of piperine on antioxidant
pathways in tissues from normal and streptozotocin-induced diabetic rats
by Rauscher FM, Sanders RA, Watkins JB 3rd.(PubMed)
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