Conjugated linoleic acid supplementation on Weight loss and Body fat composition

Conjugated linoleic acids (CLA) are a family of over 28 isomers of linoleic acid found abundantly in the meat and dairy products.
In this randomized, double-blind, placebo-controlled trial, subjects with a body mass index (BMI) of 24 to 35 kg/m(2) randomly received 1.7 g of cis-9,trans-11 and trans-10,cis-12 CLA (n = 30) or placebo (salad oil; n = 33) in 200 mL of sterilized milk twice daily for 12 wk, conducted by Kaohsiung Veterans General Hospital Pingtung Branch(1). In the sixty-three subjects completed the study (CLA, n = 30). After 12 wk, compared with the baseline, the BW, BMI, total fat mass, fat percentage, subcutaneous fat mass, and waist-to-hip ratio decreased in the CLA group (P < 0.05). The CLA group was stratified by BMI and gender. The BW, BMI, subcutaneous fat mass, and waist-to-hip ratio decreased in 27 subjects with a BMI ≥ 27, and these indices, except subcutaneous fat mass, were lower in female subjects. The levels of total cholesterol, triacylglycerol, low-density lipoprotein, and plasma fasting glucose increased, whereas those of high-density lipoprotein decreased after 3 mo of CLA treatment.

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(1) "Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population" by Chen SC, Lin YH, Huang HP, Hsu WL, Houng JY, Huang CK.