Cerebral aneurysm is defined as a cerebrovascular disorder causes
of the blood vessel to bulge or balloon out of
the wall of a blood vessel as a result of the weaken
of blood vessels and veins and occurred mostly at the bifurcations and
branches of the large arteries located at the Circle of Willis.
Diseases associated with Cerebral aneurysm
1. Von Recklinghausen's neurofibromatosis
Dr. J Baldauf and the research team at the Department of Neurosurgery,
Helios Hospital Berlin report a case of an intracranial aneurysm
associated with
von Recklinghausen's neurofibromatosis. A 34-year-old woman presented
with a history of headaches, unconsciousness and neck rigidity.
Widespread cutaneous neurofibromas were found. Investigations revealed
an aneurysm of the anterior communicating artery(28)
2. Behçet's disease
Although Cerebral aneurysms in Behçet's disease are very rare. Dr. S Nakasu and the research indicated there is a case of a 57 year old man with Behçet's disease is described, who had a
subarachnoid hemorrhage due to rupture of a peripheral
middle cerebral artery aneurysm. He
underwent a successful aneurysmal clipping. Three years later he had
seizures and was
found to have a new aneurysm on the
contralateral peripheral middle cerebral artery as well as some
radiological features
of vasculitis. After 3 months of
steroid therapy, the aneurysm disappeared. Although surgical treatment
is the first choice
for ruptured aneurysms, steroid therapy
may be effective for unruptured small aneurysms in patients with
Behçet's disease(29).
3. Marfan syndrome
Marfan syndrome
is an autosomal dominant connective tissue disorder commonly due to
mutation of the fibrillin-1 (FBN-1) gene that causes disruption of
elastic fibers in large- and medium-size arteries and predisposes to aneurysm formation and arterial dissection. Cardiovascular complications occur in most patients with Marfan syndrome, but interestingly, neurovascular complications of Marfan syndrome are rare(30).
4. Pseudoxanthoma elasticum
Although intracranial aneurysms have been associated with many
hereditary collagen disorders, the incidence of brain aneurysms in pseudoxanthoma elasticum
(PXE) appears to be exceedingly low and uncertain. There is a rare
case of a sisters with PXE who both developed intracranial aneurysms.
This report supports the previously questioned hypothetical association
between PXE and intracranial aneurysms(31).
5. Ehlers-Danlos syndrome
Ehlers-Danlos syndrome
Type IV is a heritable connective tissue disorder with frequent
neurovascular manifestations, such as intracranial aneurysms. Patients
with this syndrome
have notoriously fragile blood vessels, and the reported mortality rate
for any type of vascular surgical procedure is 40%. This syndrome is rare, however, and the complication rate of aneurysm surgery may have been overestimated(32)
6. Hypoplasia and fibromuscular dysplasia
Fibromuscular dysplasia
represents one of the more common types of arterial fibrodysplasia, a
heterogeneous group of nonatherosclerotic vascular occlusive and
aneurysmal diseases. There is a report of the first case, to the knowledge, of an elderly man with infrarenal aortic fibromuscular dysplasia associated with aortic hypoplasia, without involvement of renal arteries, and contiguous aortoiliac aneurysm(33).
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Sources
(28) http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2005;volume=53;issue=2;spage=213;epage=215;aulast=Baldauf
(29) http://jnnp.bmj.com/content/70/5/682.full
(30) http://www.ncbi.nlm.nih.gov/pubmed/21723458
(31) http://www.ncbi.nlm.nih.gov/pubmed/21423077
(32) http://www.ncbi.nlm.nih.gov/pubmed/12188938
(33) http://www.ncbi.nlm.nih.gov/pubmed/19118740
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