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Saturday, 16 September 2023

#Phytochemical #D-#TartaricAcid enhances Intestinal Absorption of P-Glycoprotein (P-gp), According to Studies

Kyle J. Norton

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be the next potential source of new medicine for the treatment of diseases with little or no side effects.

Tartaric acid is a phytochemical of the organic acid found abundantly in nuts, apricots, apples, sunflower, avocado, grapes, etc.

The study of the effects of D-tartaric acid (TA) on intestinal drug absorption in the rat model, showed a significant increase in the intestinal absorption of P-glycoprotein (P-gp), a class of conjugated proteins. rhodamine 123 and daunorubicin.

Another study of starch preparations analyzed their resistance to enzymatic digestion in vitro with the presence of inorganic (hydrochloric) and organic (citric and tartaric) acids under controlled conditions. Tannic acid showed a significantly stronger influence on starch hydrolysis than citric acid.



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Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html

References
(1) Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid by Iida A, Tomita M, Idota Y, Takizawa Y, Hayashi M.(PubMed)
(2) New starch preparations resistant to enzymatic digestion by Jochym K, Kapusniak J, Barczynska R, Sliżewska K.(PubMed)

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