Green tea may be a potential therapeutic functional food for the prevention and treatment of asthma, a chronic inflammatory disease, touching people of all ages, particularly in children, a renowned institute suggested.
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice of ginger will solve the problem.
According to the joint study led by the Ben Gurion University of the Negev, Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), a flavonoid found in green tea exhibited anti-oxidant/anti-inflammatory effects against various diseases, including asthma.
The study also demonstrated the function of Kaempferol in reducing oxidative stress through scavenging free radicals and superoxide radicals effects as well as preserving the activity of various antioxidant enzymes in attenuating the production of pro-inflammatory cytokines.
In fact, evidence from in vitro and in vivo assays postulated that aqueous fraction of green tea also exerted anti-asthmatic signaling activity in the ovalbumin-induced asthmatic model.
Furthermore, in the study of mice-induced asthma by ovalbumin, an aqueous extract of green tea displayed a potent anti-asthmatic activity by increasing the expression level of tumor necrosis factor-beta, (a protein involved in the production of one of the inflammatory cytokinin the acute phase) and interferon-gamma in the displacement of immune function against microbial infection and decreased expression of anti-asthmatic cytokines in the lung.
More importantly, green tea alleviated asthmatic symptoms by increasing the expression of Th1 cell-in, which regulated the production of interferon-gamma and interleukin (IL)-2, proinflammatory cytokines, and tumor necrosis factor.
Promisingly, another green tea constituent, namely Chafuroside A (CFA), water-soluble flavone C-glycoside, in experimental asthma/chronic obstructive pulmonary disease (COPD)-rat model, treatment with Chafuroside A at 0.5mg/kg, 1.0mg/kg could attenuate inflammatory symptoms and ameliorate antigen-induced airway inflammation, respectively.
Dr., Onoue S, the lead author in the above study said, " A self-assembled micellar (SAM) formulation might be an efficacious approach for enhancing the therapeutic potential of CFA for treatment of inflammatory diseases".
Unfortunately, there are few reports suggesting that green tea-induced asthma in tea-sensitive patients, as epigallocatechin gallate induced histamine release through IgE-mediated response.
Taken together, there is no doubt that green tea may be considered a functional food for the prevention and treatment of asthma, but people with tea-sensitive syndrome should avoid drinking green tea unless with the approval of related field specialists.
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Sources
(1) Kaempferol, a potential cytostatic cure for inflammatory disorders by Rajendran P1, Rengarajan T1, Nandakumar N2, Palaniswami R3, Nishigaki Y1, Nishigaki I4.(PubMed)
(2) An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers by Heo JC1, Rho JR, Kim TH, Kim SY, Lee SH.(PubMed)
(3) Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats by Onoue S1, Matsui T, Aoki Y, Ishida H, Nukaya H, Kou K, Yamada S.(PubMed)
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