Kyle J. Norton
Human toxicity is a general term that refers to any substance that causes harm to human health if inhaled, ingested, or absorbed through the skin.
Liver toxicity is a process that causes liver damage by reducing the function of the liver.
Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.
The liver is the largest internal organ that not only filters the blood from the digestive system before passing it to other parts of the body but also plays a critical role in the production of cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers, including transaminases aspartate transaminase (AST) and alanine transaminase (ALT).
Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.
Epidemiologically, drugs that induce liver injury are nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs (anti-tubercular drugs), anti-cancer drugs, hormonal drugs, immunosuppressive agents, and sedative and neuropsychiatric drugs.
Acetaminophen according to a study is the most common form of medication that implicates drug-induced liver injury
However, antibiotics are another class of drugs that cause liver toxicity most commonly
In finding a potent veggie against drug-induced hepatotoxicity, researchers examined sulforaphane (SFN), a thiol compound found in wide abundance in cruciferous plants against acute liver injury.
In VPA-induced liver injury in rats for 7 days, which causes significant biochemical alterations and hepatic histopathological damage, SFN (0.5 mg/kg, orally) for 7 days showed a significant protective effect against liver injury observed by the liver function biomarkers.
More precisely, levels of liver stress markers such as alanine transaminase, aspartate aminotransferase, and alkaline phosphatase were strongly reduced by the administration of SFN.
According to the tested analysis, SFN not only restored serum albumin concentration in a significant manner but also SFN significantly mitigated VPA-induced histopathological alterations.
The efficacy of SFN against liver toxicity was attributed to several mechanisms including inhibition of malondialdehyde and tumor necrosis factor α content associated with oxidative stress and the increase of concomitant increase in hepatic heme oxygenase-1 content and glutathione concentration involved in the antioxidant expression.
Based on the results, researchers wrote, "SFN can significantly ameliorate VPA-induced hepatotoxicity and liver injury primarily by a direct association between antioxidant and anti-inflammatory properties".
Taken altogether, cruciferous plants may be considered supplements for the prevention of acute liver injury, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane protects against sodium valproate-induced acute liver injury by Nazmy EA1, El-Khouly OA1, Atef H2, Said E. (PubMed)
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