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Tuesday, 19 September 2023

Coffee and #Coffee #Caffeine Inhibit Gene and Protein Expression Associated with a Reduced Risk of #Obesity, Researchers Say

Kyle J. Norton


In comparison to herbal medicine, food therapy even takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.

Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

Obesity is a medical condition of excess body fat accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity.

Good news for coffee lovers, bioactive components found in coffee may have a potential effect in reduced risk and management of obesity, a renowned institute study opinionated.

According to the joint study led by the National Taiwan University, the efficacy of coffee in reduced risk and management of obesity over the last 10 years of research, may be attributed to
1. decrease lipid accumulation in cells via the regulation of the cell cycle in fat tissue
2. improved fat metabolic formation in both protein and transcription factor expression

According to animal studies.
In humans, it is the result of decreased body weight and visceral fat stored within the abdominal cavity.

Furthermore, the study also expressed the importance of coffee intake in influencing the gut microbiota in obese animals and humans.

Additionally, in the evaluation of possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract (GCBE) in high-fat diet (HFD)-induced obese mice fed with only HFD or HFD with GCBE at 50, 100, and 200 mg/kg, respectively, researchers filed the following results
1. The treated group showed a significantly decreased body weight gain, and liver and white adipose tissue weights, but importantly intake of coffee also regulated adipose tissue lipolysis hormones in breaking down fat accumulation.

2. The efficacy of the treatment group in reduced obesity risk may also benefit the decreased mRNA expression levels of adipogenesis and adipocyte metabolism in both gene and protein expression.

3. Compared to other treated groups, GCBE-treated mice displayed a lower fat mass and relative body weight and decreased fat mass.

More importantly, in the review of papers from in vivo, ex vivo, and in vitro experimental studies in animals and human tissues as well as wide population-based epidemiological studies in the last 10 years, researchers at the joint study led by the South University School of Pharmacy said, " there is mounting evidence of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process".

Taken together, there is no doubt that coffee and coffee caffeine have a significant and potential effect in reducing risk and management of obesity, through various active biochemicals in dose deepening manner.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Coffee consumption, obesity, and type 2 diabetes: a mini-review by Santos RM1, Lima DR2.(PubMed)

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