Kyle J. Norton
Chaste tree berry is found to associate with reduced risk of liver damage and diseases through various mechanisms, the recent study suggested
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly the expression of levels of antioxidants in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.
According to Al-Hikmah University, the Hepatoprotective effects of chaste tree berries may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin levels which can also contribute to hepatoxicity.
Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".
Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase, and peroxidase levels in liver homogenate.
Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage
In fact, the extract displays an enormous hepaprotective effect similar to those of silymarin through enhancing the antioxidant mechanisms of its components, predominantly artemetin.
According to the Vinayaka Mission’s College of Pharmacy study, in the CCl4-induced hepatic injury in albino rats, vitex extracts not only comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damaged through injection of CCI4, to near normal in treated rats.
Taking together, there is no doubt that Chaste tree berries may process a protective effect in reducing the risk of harmful chemicals and drug-induced liver damage, but the injection of a large amount should be taken with care.
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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation, and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)
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