Artichoke may be the next target to extract the ingredient needed for the treatment of chronic myeloid leukemia (CML), according to studies.
Chronic myeloid leukemia (CML) is a type of cancer characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.
The exact causes of CML are unknown. Some researchers suggested that the causes of DNA alternation of the myeloid cells may be associated with the abnormal function of genes involved in cell cycle division and tumor suppression.
Epidemiologically, most people with CML are associated with risk factors of aging, male gender, and long-term exposure to radiation. However, most people with some of the risk factors do not develop CML.
According to the statistic provided by the American Cancer Society, in 2018, about 8,430 new cases will be diagnosed with CML (4,980 in men and 3,450 in women). The disease also causes the death of 1,090 people, including 620 men and 470 women.
The most common symptoms of CML include easy bleeding and tiredness, unintended weight loss, pain or fullness below the ribs on the left side, pale skin.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of the disease.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of chronic myeloid leukemia evaluated the methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of the leukocyte cancer cell.
In other words, the study was carried out to examined the effect of CCL extract on human K562 CML and K562 imatinib-resistant (IMAR) cell proliferation and on p210BCR/ABL expression.
Where p210BCR/ABL chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias.
Injection of CCL extract showed to inhibit the cell viability of both K562 CML human cell line and K562 IMAR, according to the MTT assay.
In protein implication, cynaropicrin and its deacyl derivative from the CCL extract displayed a significant capability in the inhibition of the p210BCR/ABL oncoprotein, according to the Western blot technique.
In cancer viability assay, CCL extracts exerted a similar effect compared to that of imatinib or its cancer growth arrest in CML.
In the depth differentiation, researchers also found that CCL extract also showed strong inhibition of the delay or overcome the resistance of CML to chemotherapy.
Taken together, artichoke with the abundantly bioactive compounds may be considered a functional remedy for the prevention and treatment of chronic myeloid leukemia with no side effects, pending to the confirmation of larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia by Russo A1, Perri M1, Cione E1, Di Gioia ML1, Nardi M1, Cristina Caroleo M. (PubMed)
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