Pages

Friday, 30 June 2023

#CarrotExtract inhibits #Obesity by Preventing the Exacerbation of Lipid and Glucose Metabolism Associated with WeightGain, Researchers Show

Kyle J. Norton

Carrots may have a profound and positive effect in reducing weight loss in the obese population, some scientists suggested.
Weight loss is an intentional action referred to by the medicine, health, or physical fitness communities as a reduction of the total body mass, including loss of fluid, body fat or adipose tissue, or lean mass.

Obesity is a condition or disease characterized by extreme weight. According to the Body Mass Index calculator, BMI between 25.0 to <30 is considered overweight and a BMI of 30.0 or higher, is considered obese.


According to the National Institue of Health, obese people are associated with a number of diseases and conditions, including diseases of coronary heart disease, type 2 diabetes, certain types of cancer, stroke, gallbladder disease, liver disease, certain types of respiratory disease, and infertility and conditions of high blood pressure, high total cholesterol or high levels of triglycerides, sleep apnea, and osteoarthritis.

Most researchers agreed that obesity is caused by a genetic mutation inherited from the parents, a long-term unhealthy diet with consumption of high amounts of energy foods, particularly fat and sugars, and physical inactivity.

Other causable factors also include certain medical conditions such as hypothyroidism and Cushing's syndrome and long-term use of certain medications such as corticosteroids and depressants.

The general belief also suggested that some smokers may gain weight if they quit smoking.

According to the study conducted by the J University of Georgia, using a combined approach to promote nutrition and physical activity policies and practices in early care and education may reduce the risk of child obesity.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.

Estrogen-deficient animals with diet-induced obesity were examined in the study by the Obesity/Diabetes Center, Asan, Korea using black carrots to test the mechanisms of the long-term consumption of unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) or Aspergillus oryzae (BCAO) in the prevention of menopausal symptoms including impaired energy, glucose and lipid metabolism


During the experiment, ovariectomized (OVX) rats were fed four different high-fat diets containing 2 % dextrin (OVX-control), 2 % BC, 2 % BCLP, or 2 % BCAO for 12 weeks. Sham rats were fed high-fat diets containing 2 % dextrin.

Fat mass and weight gain in tested mice were lower in descending order of OVX-control > BC and BCLP > BCAO due to increased energy expenditure and fat oxidation.


BC, BCLP, and especially BCAO all normalized HOMA-IR, an indicator of insulin resistance and glucose intolerance.


Furthermore, BCAO markedly decreased hepatic triglyceride levels by increasing gene expressions of CPT-1 and PPAR-α, which are involved in fatty acid oxidation, and decreasing mRNA expressions of FAS and SREBP-1c, which are associated with fatty acid synthesis.

More importantly, Cyanidin and malvidin markedly decreased fat accumulation in 3T3-L1 adipocytes by increasing CPT-1 and decreasing FAS expression in the liver fat metabolism and SREBP-1c expression in the regulation of the genes with the function of lipid metabolism in comparison with cyanidin-3-rutinoside, an anthocyanin, and malvidin-3,5-glycosides, another anthocyanidin.

Where 3T3-L1 is a cell line derived from 3T3 cells used in biological research on adipose tissue.

These results suggested that unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) processed the anti-obesity mechanism by preventing the exacerbation of lipid and glucose metabolism, the major causes of weight gain.

However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of carrot's anti-weight gain possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid, and glucose metabolism in estrogen-deficient rats by AMPK activation by Park S1, Kang S, Jeong DY, Jeong SY, Park JJ, Yun HS. (PubMed)

No comments:

Post a Comment