Cayenne Pepper in Reducing the Risk of Metabolic Dysregulation

By Kyle J. Norton

Cayenne pepper may be the next herbal medicine in reduced risk and treatment of metabolic dysregulation, a recent study suggested

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum Annuum, the family Solanaceae, native to subtropical and tropical regions. It has been used in traditional medicine to increase metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

Metabolic dysregulation refers to abnormal function of the body in regulation of glucose tolerance, fasting glucose, insulin resistance, dyslipidemia,...., leading to insulin resistance, type 2 diabetes, and fatty liver disease.

Capsaicin, the major chemical compound used in dietary supplements attenuated metabolic dysregulation in genetically obese diabetic mice by enhancing expression of modulation of glucose and lipid metabolism involving its receptors.

In obesity-induced inflammation and the development of obesity-related metabolic disorders, cayenne capsaicin suppressed inflammatory responses in inducing glucose intolerance and enhancing fatty acid oxidation in fat tissues, affecting insulin resistance.

The chemical compound involvement in reduced visceral adipose fat, also lowered serum levels of fasting glucose, total cholesterol, and triglycerides, probably through limited fat accumulation in adipose tissues and reduced inflammation, and increased insulin sensitivity.

Dr. Leung FW. said," Clinical evidence supports the role of capsaicin as an anti-obesity agent. Both oral and gastrointestinal exposure to capsaicin increase satiety and reduce energy and fat intake and reduction in visceral abdominal fat" and "Thermogenesis and lipid metabolism-related proteins are altered upon capsaicin treatment in white adipose tissue".

Intake of cayenne for weight loss treatment-induced reduction in visceral abdominal fat may also improve metabolic regulation. Quality of doses should only be given by specialists to prevent toxicity.

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Sources
(1) Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice by Kang JH1, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R.(PubMed)
(2) Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet by Kang JH1, Goto T, Han IS, Kawada T, Kim YM, Yu R.(PubMed)
(3) Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice by Lee GR1, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH, Han IS.(PubMed)