Tocopherols Lower the Risk of Gallstone Diseases

By Kyle J. Norton

The gallbladder is a small organ under the liver with a function of aiding the digestive system in fat metabolism and storing of the bile produced by the liver.

The gallbladder also plays a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.

Gallbladder disease is a condition of inflammation or gallstones of the gallbladder.
A gallstone is a stone formed within the gallbladder out of bile components as a result of building up undissolved cholesterol over a prolonged period of time.

Gallstones can cause blockage of the flow of bile through the bile ducts,  leading to inflammatory causes of acute cholecystitis. Gallstones are most common among older adults, women, overweight people, etc.

According to the statistic, approximate 20 millions of the US population have some kinds of Gallbladder Disease.

The most common symptoms are

* Upper gastrointestinal bleeding if ruptured

* Right upper quadrant or midline epigastric pain

*  Abdominal pain
Gallstones are relatively rare in children. Some gallstones are radiopaque and can be visualized on plain abdominal radiography.

* Other symptoms may include mid-upper abdominal pain,  biliary pain, and colic.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of digestive diseases, researchers examined the effect of tocopherols on gallstone diseases.

According to the analysis of plasma levels of α- and γ-tocopherol using high-performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women),

* Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13-0.76).

* γ-tocopherol/cholesterol ratio showed a lower probability of having gallstone disease. However, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35-1.69 for 3rd vs 1st tertile).

In other words, levels of α-tocopherol associated with levels of cholesterol showed a significant lowering the risk of gallstone diseases, compared to the ratio of γ-tocopherol/cholesterol

After talking about other factors into account, researchers said, "our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies.".

Taken altogether, tocopherols may be considered adjunct therapies in the treatment of gallstone diseases, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease by Waniek S1, di Giuseppe R2, Esatbeyoglu T3, Ratjen I4, Enderle J5, Jacobs G6,7, Nöthlings U8, Koch M9,10, Schlesinger S11, Rimbach G12, Lieb W. (PubMed)

Healthy Food, Broccoli's Bioactive Ingredient Quercetin Is Effective in Modulating the Immune Response, According to Study

By Kyle J. Norton

Immunomodulators are agents that modify the immune response or the functioning of the immune system such as the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.

In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending on the body's needs.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.

The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.

Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.

In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.

These activities played an important in inducing apoptosis and reducing the proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.

Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On findings a natural wholefood for the prevention of infectious disease, researchers examined the effects of Quercetin, a great representative of polyphenols, flavonoids subgroup, flavonols found in broccoli on the immune response.

Quercetin exhibited antioxidant activity in radical scavenging and anti-allergic properties by stimulation of the immune system against the antiviral activity, histamine release,


Furthermore, quercetin also modulated the immune response by decreasing the pro-inflammatory cytokines, leukotrienes creation, and suppressing interleukin IL-4 production.

The antioxidant improved the Th1/Th2 balance, and restrain antigen-specific IgE antibody formation.

Moreover, quercetin was also effective in the inhibition of enzymes such as lipoxygenase, eosinophil, and peroxidase by suppressing inflammatory mediators.

Based on the results, researchers wrote, " All mentioned mechanisms of action contribute to the anti-inflammatory and immunomodulating properties of quercetin that can be effectively utilized in the treatment of late-phase, and late-late-phase bronchial asthma responses, allergic rhinitis, and restricted peanut-induced anaphylactic reactions".

And "Plant extract of quercetin is the main ingredient of many potential anti-allergic drugs, supplements and enriched products".

Taken altogether, broccoli containing high amounts of quercetin may be considered a functional food for the improvement of the immune response, pending confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin and Its Anti-Allergic Immune Response by Mlcek J1, Jurikova T2, Skrovankova S3, Sochor J. (PubMed)

Omega -3 Fatty Acids Eradicate Glioblastoma Cells in Vitro and Vivo

By Kyle J. Norton

The central nervous system is a part of the nervous system of the brain and spinal cord with the function of integrates information it receives from for the entire nervous system, and control all the workings of your body.

The brain controls our thoughts, memory and speech, movement of the arms and legs, and the function of many organs within our body, through a complex system involved neuron messages transmitting

A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.

Glioblastoma is one of the most aggressive cancers that begins within the brain.

According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.

If you are male, you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.

The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.

Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of neurological diseases, researchers examined the cytotoxic effect of DHA on the GBM cell lines, D54MG, U87MG, U251MG, and GL261.

According to the results of differentiation
* Treatment of GBM cells with DHA induced PARP cleavage associated with cell death by increasing the population of sub-G1 cells and the number of TUNEL-positive cells with apoptotic DNA fragmentation.

* Furthermore, treatment of GBM cells with DHA exerted a significant increase in autophagic activity, accompanied by activation of 5'-AMP-activated protein kinase (AMPK) induced uptake of oxidative stress and decreases in phosphorylated Akt (p-AktSer473) levels and mTOR activity in the promotion of tumor growth.

In vivo, conversion of ω6-PUFAs to ω3-PUFAs, in fat-1 transgenic mice yielded a significant decrease in tumor volume following subcutaneous injection of mouse glioma cells (GL261), when compared with wild-type mice.

Moreover, the conversion also elevated the TUNEL-positive cell numbers and LC3-II levels in tumor tissue from the fat-1 transgenic mice compared with tumor tissue from the wild-type mice.

Additionally, p-Akt levels in the promotion of cell proliferation and cell survival were decreased compared to the increase of tumor suppressor p-AMPK levels in tumor tissue from the fat-1 transgenic mice.

Based on the findings, researchers said, " ω3-PUFAs induce cell death through apoptosis and autophagy in GBM cells; thus, it may be possible to use ω3-PUFAs as chemopreventive and therapeutic agents for GBM".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of glioblastoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo by Kim S1, Jing K2, Shin S1, Jeong S1, Han SH1, Oh H1, Yoo YS1, Han J1, Jeon YJ1, Heo JY1, Kweon GR1, Park SK1, Park JI1, Wu T3, Lim K. (PubMed)

Herbal Medicine, Cat's claw Processes Immunomodulatory Activity Against the Onset of Inflammatory Disease, According to Studies

Kyle J. Norton


Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

Inflammatory diseases are disorders and conditions caused by inflammation. Cat's claw may be the next generation of medical plants for the treatment of inflammation against various diseases. According to the study by the Case Western Reserve University, Uncaria tomentosa exhibited high levels of anti-inflammatory effects through the interference of the pro-inflammatory expression.

Mitraphylline (MTP), the major pentacyclic oxindole alkaloid presented in Uncaria tomentosa, elicited an anti-inflammatory response that modulates neutrophil activation contributing to the attenuation of inflammatory episodes.

Furthermore, the ingredient, Mitraphylline (MTP) also showed a direct effect on the immune system by reduced almost 40% of the production of interleukin 4 (IL-4) and inhibited around 50% of the release of interleukins.

Indenture Stomatitis, a chronic oral disease that affects denture wearers is caused by Candida Albicans in inducing inflammation. Topical application of a gel of 2% U. tomentosa three times a day for 1 week, cat' claw significantly reduced signs of the disease, after 1 week of treatment.

In fact, the anti-inflammatory properties may also result from their ability to inhibit TNF-alpha, a central regulator of inflammation, and to lesser production of PGE2, a principal mediator of inflammation in disease production.

The effects of cat's claw in inhibited inflammatory diseases may result from its binding to proinflammatory cytokines and pathways. Use of the medical plant should be only prescribed by herbal for safety purposes.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes by Akhtar N1, Miller MJ, Haqqi TM.(PubMed)
(2) Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils by Montserrat-de la Paz S1, Fernandez-Arche A2, de la Puerta R2, Quilez AM2, Muriana FJ3, Garcia-Gimenez MD2, Bermudez B4.(PubMed)
(3) Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark by Rojas-Duran R1, González-Aspajo G, Ruiz-Martel C, Bourdy G, Doroteo-Ortega VH, Alban-Castillo J, Robert G, Auberger P, Deharo E.(PubMed)
(4) Uncaria tomentosa Gel against Denture Stomatitis: Clinical Report by Tay LY1, Dos Santos FA, Jorge JH.(PubMed)

Cruciferous Vegetables May Process Anti Inflammatory Activity, According to Studies

By Kyle J. Norton

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management, and treatment of diseases has induced much interest in today renowned scientists.
But many researchers have raised questions of herbal quality, because geographic differences, time of grown and harvest, etc. may affect their's potency. I do believe, these questions can only be answered by experienced herbalists.

Intake of cruciferous vegetables may be inversely correlated with circulating proinflammatory levels in women.

In a total of 1,005 middle-aged Chinese women study, consumption of cruciferous vegetables regularly is associated to lower circulating concentrations of proinflammatory cytokines.

Proinflammatory cytokines, also known as Interleukin (IL) and tumor necrosis factor (TNF), secreted by the immune system to protect our body in inducing fever, inflammation, tissue destruction, etc.


Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Further to the study, Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells exhibited the induction of apoptosis in the cancer cell line, through the involvement of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin.

Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through an induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.

Other phytochemicals found in the vegetables, such as 3,3'-diindolylmethane (DIM), a derivative of indole-3-carbinol, also expressed anti-pro-inflammatory effects through interleukin (IL)-1beta, IL-6, and tumor necrosis factor.

 
In fact, chemical compounds found in the vegetable, not only inhibited the pro-inflammatory cytokines in the expression of chronic diseases and cancers but also involved in other aspects, such as environmental airborne particulate pollutants, according to the East Campus - Laurentian University.


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Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH.(PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)

Queen Herb, Chaste Tree Berry May Process Anti-Aging Chronic Diseases Activity, Researchers Find

By Kyle J. Norton

Chaste tree berry may process a strong effect in reduced the risk of free radical progression in inducing various diseases, the renowned institute suggested.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Antioxidants are chemical compounds with the function of inhibited oxidation caused by the production of free radicals with an aim to reduce the risk of oxidative damage to our body.

According to the Faculty of Pharmacy, Ege University, in the observation of the chemical activity of different preparation s of Chaste tree berry, researchers showed that water and ethanol extract content is far stronger antioxidant activity in compared n-hexane extracts.

In vitro antioxidant assays, the newly differentiated ingredients isolated from the Chaste tree berry, EtOAc extract displayed a significant antioxidant property in reduced free radicals caused by brain homogenate. at the concentration-dependent effect tested by 1,1-diphenyl-2-picrylhydrasyl (DPPH) free radical assay (IC(50) = 68 microg/mL) in compared fractions of MeOH-H(2)O and n-hexane fraction.


The study also suggested that the efficacy of antioxidant effect in the extract may have resulted from the recently discovered phytochemicals, flavonoid constituents EtOAc extract, casticin, vitexin, and orientin as viewed in the tested essay.


More importantly, in support of the above differentiation, a study of mice subcutaneously injected with d-galactose (500 mg/kg/d for 45 days) induced aging and natural aging. administrated extract of Vitex (600 mg/kg/bid for 7 days by gavage) to 72 female NMRI mice (48 3-month-old normal mice and 24 18-24-month-old mice), weighing 30-35 g randomly divided into six groups: control, Vitex, d-galactose, Vitex + d-galactose, Aging, and Vitex + Aging, groups treated with chaste tree berry expressed a superior effect in restored estrous cycle and damage of uterus and ovarian tissues, through antioxidant activities in ameliorated oxidative stress and aging diseases.

Truly, mice treated with extract of Chaste tree berry only showed a reduced presence of free radicals but also improved hormone expression in natural and d-galactose induced aging.

Taking together, there is no doubt that Chaste tree berry displayed a significant antioxidant potential in ameliorated the risk of free radicals in induced chronic diseases, but a large amount of intake should be taken with care.


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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


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Sources
(1) Antioxidant activity of Vitex agnus-castus L. extracts by Sağlam H1, Pabuçcuoğlu A, Kivçak B.(PubMed)
(2) Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents by Hajdú Z1, Hohmann J, Forgo P, Martinek T, Dervarics M, Zupkó I, Falkay G, Cossuta D, Máthé I.(PubMed)
(3) Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model by Ahangarpour A1, Najimi SA2, Farbood Y3.(PubMed)

Healthy Foods Dried Peas and Dried Beans Ameliorate the Risk and Treatment of Colon Cancer in Vivo and Human Studies

By Kyle J. Norton

Dietary factors can influence cancers formation and growth, intake of dried peas may have a potential effect in reduced risk of colon cancer, a recent study suggested

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with a healthy source of proteins, fibers, vitamins, and minerals.

Colon cancer is a condition characterized by cell growth disorderly and irregularly in the tissues of the colon.

A case-control designed study of 186 men and women with a mean of 58 years of age revealed that consumption of legumes such as dried beans, split peas, or lentils daily and regularly was inversely associated with reduced risk of colon cancer, after adjusting all potential confounding variables.

The relative risk odd ratio of colon cancer occurrence in these subjects was ameliorated substantially in comparison to control.


Researchers also indicated that the risk of colon cancer decrease may be attributed to legumes dietary fiber together with enormous presences of phytochemical compounds.
Dr. Agurs-Collins T, the led author said, "Nurses working with African-Americans should encourage consumption of these foods to decrease this risk".

Others, in the study of the same subject, suggested that by modifying diet and lifestyle habits, adenomatous polyps and 25-35% of colon adenoma risk could be avoidable. As consumption of legumes at least 3 times/wk reduced the risk of colon cancer by 33% after adjusting for meat intake.

Furthermore, the research result also postulated that a high frequency of consumption of cooked green vegetables, dried fruit, legumes, and brown rice was associated with a decreased risk of colorectal polyps.

Interestingly, in the investigated effect of consumption of standard diets supplemented with freeze-dried vegetables (peas, spinach, sprouts, and broccoli) and carotenoids (all-trans beta-carotene and palm oil carotenoid extract) on surrogate end-point markers for colorectal cancer in an azoxymethane-induced rat model, researchers at the Unilever Research Vlaardingen, illustrated that
peas, spinach, sprouts, and a mix of all vegetable diet expressed a significantly reduced the number of foci with >2 aberrant crypts/focus by 37, 26, 23, and 26%, particularly in the pea and spinach intervention groups.


After adjusting to other risk factors, researchers filed the following reports
1. Peas, spinach, sprouts, and a mix of all vegetable diet was beneficial effects in reduced risk of colorectal carcinogenesis
2. Consumption of several types of vegetables inhibits the early onset of colorectal carcinogenesis
3. and suggest that the vegetable-induced effect is more pronounced in advanced lesions.

Taking all together, dried peas may be used as therapeutic ingredients in reduced risk and treatment of colon cancer and diseases related to colon abnormalities.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.




Sources
(1) Legume intake and reduced colorectal adenoma risk in African-Americans by Agurs-Collins T1, Smoot D, Afful J, Makambi K, Adams-Campbell LL(PubMed)
(2) Foods and food groups associated with the incidence of colorectal polyps: the Adventist Health Study by Tantamango YM1, Knutsen SF, Beeson WL, Fraser G, Sabate J.(PubMed)
(3) Effect of vegetable and carotenoid consumption on aberrant crypt multiplicity, a surrogate end-point marker for colorectal cancer in azoxymethane-induced rats by Rijken PJ1, Timmer WG, van de Kooij AJ, van Benschop IM, Wiseman SA, Meijers M, Tijburg LB.(PubMed)

Green Tea Decoction GTD (2/3 Epigallocatechin Gallate (EGCG)+1/3 Epigallocatechin EGC) Reduces Weight Gain and Promotes Weight Loss, Researchers Say

Kyle J. Norton 

Green tea polyphenols may have a therapeutic effect in reduced weight gain through decreased hormone expression with function direct influence of excess energy deposit, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Weight gain is an increase in body weight, involved an increase in muscle mass, fat deposits, excess fluids.

In the compared green tea, polyphenols [epigallocatechin gallate (EGCG), epigallocatechin (EGC)] in a decoction of green tea leaves versus usual green tea extracts to evaluate the effect in weight gain in obese animal models fed with a high-fat diet, researchers after taking into account of other con-founders suggested that green tea decoction acute administration of GTD with 2/3 EGCG+1/3 EGC inhibited SGLT-1 activity involved distinct and complementing glucose homeostasis through absorbing glucose from the diet in the small intestine and by reabsorbing the filtered glucose in the tubular system of the kidney, thus reducing access energy being converted to glycogen or fat and deposit in liver, muscles and fat cells.

Additionally, green tea decoction not only improved glucose tolerance but also demonstrated a significant increase in GLUT2 protein in facilitated glucose movement across cell membranes in the regulation of glucose absorption in the distribution of dietary sugar to tissues to induce calorie restriction.

Chronic administration of green tea decoction GTD for 6 weeks, in the same experiment models, also displayed a huge reduction of body weight gain, circulating triglycerides and cholesterol, and improved glucose tolerance, through significantly reduced SGLT-1 as seen in an acute application and increased GLUT2 mRNA levels in the jejunum mucosa with function in increase the surface area of tissue available to absorb nutrients from ingested foodstuffs for decreased fat accumulation and glucose in the liver.


Dr. Snoussi C, the lead author said, "GTD-treated rats for 6 weeks display significantly reduced SGLT-1 and increased GLUT2 mRNA levels in the jejunum mucosa". This result showed that green tea decoction with polyphenols such as epigallocatechin gallate (EGCG), epigallocatechin (EGC) may have a certain effect in reduced weight gain through decreased fat deposit in the liver and promoted calorie restriction.

Further analysis of C57BL/6J mice fed a high-fat/high-sucrose diet (HF/HS, 32% energy from fat; 25% energy from sucrose) or the same diet supplemented with 0.25% GTP or BTP or a low-fat/high-sucrose (LF/HS, 10.6% energy from fat, 25% energy from sucrose) diet for 4 weeks showed that treatment with decaffeinated green tea (GT) polyphenols inhibited weight gain in mice fed an obesogenic diet as indicated above, through the rearrange the relative proportions of Blautia, Bryantella, Collinsella, Lactobacillus, Marvinbryantia, Turicibacter, Barnesiella, and Parabacteroides is correlated with weight loss by a decrease of cecum Firmicutes and increase in Bacteroidetes in the gastrointestinal tract.
Indeed, GTP not only induces weight loss in association with alteration of the gut microbiota but also increased hepatic AMPK in reaction in sugar metabolism, and energy storage and release.

Interestingly, according to the START Clinic for the Mood and Anxiety Disorders, oral administration of green tea extract induced an unexpected decrease in total body fat mass, a decrease in body fat percentage, and an increase in lean body mass in patients with weight gain induced by psychotropic medications.


Taken together, green tea, bioactive active polyphenols epigallocatechin gallate (EGCG), epigallocatechin (EGC) may be used as a functional food in reduced weight gain induced by all sources and increased weight loss through regulation of energy metabolism in fat accumulation.


For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal of Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice by Henning SM1, Yang J2, Hsu M2, Lee RP2, Grojean EM2, Ly A2, Tseng CH3, Heber D2, Li Z2. (PubMed)
(2) Green tea decoction improves glucose tolerance and reduces weight gain of rats fed a normal and high-fat diet by Snoussi C1, Ducroc R2, Hamdaoui MH3, Dhaouadi K4, Abaidi H3, Cluzeaud F2, Nazaret C2, Le Gall M2, Bado A5. (PubMed)
(3) Weight gain and psychiatric treatment: Is there a role for green tea and conjugated linoleic acid? by Katzman MA1, Jacobs L, Marcus M, Vermani M, Logan AC. (PubMed)

Herbal Anise's Anethole Reduces the Risk, Progression and Treatment of Osteoporosis, Scientists Suggest

Kyle J. Norton


Anise may have a potential and substantial effect in reduced risk and progression and treatment of osteoporosis, some scientists suggested.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...

Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the investigation of the herbal selective estrogen receptor modulators or SERMs effect in risk of osteoporosis, in comparison of plant aqueous extracts derived from Greek flora (Sideritis euboea, Sideritis clandestina, Marticaria chamomilla, and Pimpinella anisum), researchers at the Medical School, University of Athens found that all extracts exert profound activities in stimulated the differentiation and mineralization of osteoblastic cell culture.

Further analysis, also discovered that all plant extracts at concentration range 10-100 microg/mL, including Anise induced osteoblastic cell differentiation in formation of bone and improved bone density.

These results indicated that Anise and other plant extracts may comprise a substantial anti-estrogenic effect in reduced risk of osteoporosis in a dose-dependent manner.


Also, in the evaluation of (E)-anethole, a major bioactive compound isolated from Anise protective effect on H2O2-induced alterations in collagen metabolism, researchers showed that application of anethole of 0.5 µM for 1 h completely prevent the alternation of cells treated with 300 µM H2O2 in displayed a decrease in collagen biosynthesis of 54 %, correlated with alterations of type I collagen mRNA expression in the osteoblasts in initiated higher bone turn over.


Additionally, differentiation also revealed that Anise anethole administration at 10 µM, exerts the most efficient suppression in the ameliorated expression of MMP-2 and MMP-9 caused by H2O2 induced alterations in collagen metabolism, in contributing to the 8 % decrease in the amount of collagen secreted into the medium.

The result suggested that the application of H2O2 not only directly activates MMPs but also causes a decrease in the expression of their inhibitors, such as TIMP2, a metastasis suppressor in initiated alterations of collagen metabolism in bone.

In Other words, anethole isolated from Anise attenuated ROS causes increased activity of matrix metalloproteinases (MMPs) in degraded collagen in fibroblasts.
Some researchers suggested, "the loss of MMP-9 improved the connectivity density of the trabeculae, whereas the loss of MMP-2 reduced this parameter. Similar differential effects in architecture were observed in the L5 vertebra, but bone volume fraction was lower for both MMP-2 and MMP-9 (in mice study) "


Taken together, Anise and its bioactive anethole may be considered as a functional herb for reduced risk and treatment of osteoporosis caused by collagen loss in skin and bone. However, intake of Anise supplement should be taken with extreme care in prevented toxicity.

For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal of Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties by Kassi E1, Papoutsi Z, Fokialakis N, Messari I, Mitakou S, Moutsatsou P.(PubMed)
(2) Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblast by Anna Galicka, Rafał Krętowski, Jolanta Nazaruk, and Marzanna Cechowska-Pasko(PubMed)
(3) Differential Effects Between the Loss of MMP-2 and MMP-9 on Structural and Tissue-Level Properties of Bone by Jeffry S Nyman,1,2,3,4 Conor C Lynch,5 Daniel S Perrien,2,3 Sophie Thiolloy,6 Elizabeth C O’Quinn,2,7 Chetan A Patil,4 Xiaohong Bi,2,4 George M Pharr,8,9 Anita Mahadevan-Jansen,4 and Gregory R Mundy(PMC)
(4) Osteoporosis, a unitary hypothesis of collagen loss in skin and bone by Shuster S1.(PubMed)

Mixture of Kale (Brassica Oleracea) and Payapa Shows Promising Results for the Treatment of Colitis in Vivo

By Kyle J. Norton

Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

There is no exact cause of colitis. Certain risk factors such as colon infection, inflammatory bowel disease (Crohn's disease, ulcerative colitis), ischemic colitis, allergic reactions, and microscopic colitis have been found to increase the risk of the onset of the condition.

The most common symptoms of colitis are totally depending on the types, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Types of colitis according to the Catholic University of the Sacred Heart, are including
Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).

Some cases of colitis are also induced by the overactive immune system in the response of unharmful allergens.

Most common symptoms of colitis depending on the cause of the disease, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Some patients in the early phase of colitis may also experience symptoms of fever, chills, fatigue, and skin inflammation.

If you experience some of the aforementioned symptoms, please make sure that you check with your doctor to rule out the possibility.

Treatment of colitis is totally depending on the causes. Infected colitis is treated with antibiotics. 

However, treatment of non-infection colitis is focusing on symptoms relief, supportive care, and maintaining adequate hydration and pain control.

If you are taking antibiotics for the treatment of colitis, please discuss the side effect with your doctor.

Kale is a species of Brassica Oleracea, belonging to the family Brassicaceae, native to coastal southern and western Europe. Since kale's leave is highly nutritious and easy to grow with a range of long season from the middle of winter through the beginning of spring, it is cultivated as foods in most parts of Europe.

On finding a potential wholefood for the treatment of colitis researchers examined the evaluate the effect of dried vegetables as a prebiotic and as an intestinal anti-inflammatory in the rat colitis model.

Rats selected to the study were given orally, 500 mg/kg of rat weight of three treatments of dried vegetables: papaya, kale and the mixture of both vegetables (60% of kale plus 40% of papaya) with colitis were induced by intracolonic administration of trinitrobenzene sulfonic acid (TNBS) after the two weeks of treatment.

According to the prebiotic assay, administration of the mixture showed to modulate the bacterial flora in both the healthy rats and rats with colitis induced by TNBS compared to the veggie individual treatment

Furthermore, the application of the mixture showed a strong intestinal anti-inflammatory effect in the colitic rats observed by the reduced levels of pro-inflammatory colonic iNOS, TNFa and IL-1b  expression

Taken altogether, kale used a combination with  papaya may be considered a mixture for the treatment of colitis




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of kale and papaya supplementation in colitis induced by trinitrobenzenesulfonic acid in the rat Cibele Lima de Albuquerque a,*, Monica Comlada b , Desiree Camuesco b , Maria Elena Rodrı´guez-Cabezas b , Anderson Luiz-Ferreira a , Ana Nieto c , Alba Regina Monteiro de Souza Brito a , Antonio Zarzuelo b , Julio Ga´lvez. (EL SEVIER)

Phytochemical Omega -3 Fatty Acids Process Anti-Hyperglycemic Activity, According to Studies

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Although hyperglycemia is a hallmark in patients with diabetes, the condition can also occur to people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Most cases of hyperglycemia occurred in patients who do not manage diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body's inability to make enough insulin.

The most common causes of hyperglycemia are associated with an uncontrolled diet, improper use of insulin and skip diabetic medication.

The most common symptoms of hyperglycemia are increased thirst frequent urination, fatigue (weak, and unintended weight loss. In severe cases, some patients may also experience symptoms of headaches, trouble concentrating and blurred vision.

Most cases of hyperglycemia can be controlled by the following diabetes guidance.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of diabetic complications, researchers examined a combination of plant sterols (PS) and omega-3 fatty acids synergistic effect on impaired glucose regulation (IGR).

A total of 200 participants were randomized to receive PS and omega-3 fatty acids (n = 50), PS alone (n = 50), omega-3 fatty acids alone (n = 50), or placebo soybean powder plus placebo capsules (n = 50) for 12 weeks. 

According to the results of the experiment, 

* Compared to the placebo group, the group receiving the combined intervention exhibited significantly decreased TG, HDL-C, fasting plasma glucose (FPG), Insulin Resistance (HOMA-IR)) and glycosylated hemoglobin (HbA1c).

* Omega-3 fatty acids alone were associated with significant reductions in waistline, TG, FBG, HOMA-IR, and Hs-CRP.

* The combined ap[plication also exerted no significant changes in body weight, BMI, blood pressure, FINS, body fat percentage, visceral fat rating, TC, LDL-C or IL-6.

Based on the findings, researchers said, " this study has demonstrated for the first time that PS, omega-3 fatty acids or the combination thereof significantly improved inflammation, insulin resistance, as well as glucose and lipid metabolism in IGR individuals".

Taken altogether, Omega-3 fatty acids together with plant sterols (PS)  may be considered a supplement for the treatment of hyperglycemia-induced by IGR,  pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A combination of omega-3 and plant sterols regulate glucose and lipid metabolism in individuals with impaired glucose regulation: a randomized and controlled clinical trial by Wang JF1, Zhang HM2, Li YY1, Xia S3, Wei Y1, Yang L1, Wang D1, Ye JJ1, Li HX1, Yuan J1, Pan RR. (PubMed)

Queen Herb Chaste Tree Berry Protects and Restores Internal Eye Structures Against Cataract Formation, Scientists Find

Kyle J. Norton

Today, many whole herb ingredients worked together in herbal plants were proven effective in reduced risk and treatment of various diseases with little or no side effects by many respectable scientists through intensive research and studies. However, intake of synthetic versions of single-ingredient isolated from such plants may produce opposite outcomes.

A recent study suggested that chaste Tree Berry may be used to protect the internal structures of the eyes against selenite-induced cataractogenesis.

Selenite cataract is a rapidly-induced, convenient model for the study of age-related (senile) cataracts.

Selenite, named from the Ancient Greek word for the Moon. is a crystal-like substance of mineral gypsum, composed of calcium sulfate dihydrate. It is one of the Chinese herbs used for the treatment of heat and fire syndromes.

Long-term contact with the crystal may cause side effects of headache, unstable emotional expression,..... and dizziness.

Cataractogensis is a process of cataract formation.

Cataract, one of common vision loss in people over age 40 and a leading cause of blindness, is a condition of blur vision caused by clouding of the lens in one or both eye(s).

According to statistics provided by Laser Eye Surgery Hub, In England, 30% of people 65 years or older have a visually impairing cataract in one or both eye(s). 10% of people 65 or over had already had cataract surgery. 95% of cataracts are age-related, usually after age 40.

There are many causes of cataracts, some researchers suggested that aging and injury that cause the changes in the tissue made up the eye's lens, past eye surgery, or medical conditions such as diabetes are the common causes of the disease.

However, some inherited genetic disorders such as chromosome abnormalities, Lowe syndrome,,,,

and neurofibromatosis type 2, also are associated to increase risk of cataracts too.

Believe it or not, cataracts can also be caused by other eye conditions.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region.

The herb has been used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.


According to the University of Kerala, flavonoids found in the chaste tree berry exerted a cataract protective effect in prevented damage of lenticular membrane and abnormal fiber structure in patients with cataract viewed through electron microscopy.

Furthermore, the study also found that chaste tree berry expresses a significant improvement of chaperone property of α-crystallin and soluble protein levels in two-dimensional-polyacrylamide gel electrophoresis (2D-PAGE) and immunoblot analysis.

α-crystallin, a structural lens protein plays an important role in protecting the eyes against the formation of eye diseases, including cataracts.

Dr. Rooban BN, the lead author said, " FVN modulated selenite induced cataractogenesis in rat pups by preventing loss of chaperone property, various changes in lens proteins, and lens structure, further strengthening its protective role".

Some researchers suggested that the efficacy of chaste tree berry in reduced risk and treatment of cataract may be a result of phytochemical antioxidants activity in scavenging free radicals that cause oxidative stress, loss of calcium homeostasis, calpain activation, and protein insolubilization.

More importantly, in a study of eight-day-old Sprague-Dawley rat pups divided into four groups: Control (G I), Sodium selenite-induced (G II), Sodium selenite+quercetin treated (G III), Sodium selenite+flavonoids from Vitex negundo (FVN) (G IV), group fed with sodium selenite+flavonoids showed normal levels of expression of the lens of water-soluble proteins in compared to other groups.

In fact, pups treated with FVN was found to exhibit the antioxidant effects in modulating biochemical parameters against selenite-induced cataract, the University of Kerala insisted.

In support to the above differentiation, the Sprague-Dawley rat pups of 8 days old divided into control (G I), selenite induced (G II), and selenite + V. negundo treated (G III) with cataract induced by the single subcutaneous injection of sodium selenite (4 mg/kg body weight) on the tenth day and V. negundo (2.5 mg/Kg body weight) administered intraperitoneally from eighth to 15th-day study, researchers showed that group III exerts significantly reduced activities of superoxide dismutase, catalase, lower level of reactive oxygen species, Ca(2+), and thiobarbituric acid reactive substance.

Taking together, Chaste tree berry may process therapeutic potential used for prevention of changes of internal eye structures that stimulated onset of cataract and treatment of cataract with little adverse effects.

However, additional large sample size and multi-center clinical trials with human consumption during the course of the disease are necessary to re-confirm chaste tree berry anti cataract possibility.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal of Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models by Rooban BN1, Sasikala V, Sahasranamam V, Abraham A.(PubMed)
(2) Vitex negundo attenuates calpain activation and cataractogenesis in selenite models by Rooban BN1, Lija Y, Biju PG, Sasikala V, Sahasranamam V, Abraham A.(PubMed)

Arnica's Bioactive Sesquiterpene Lactones Block the Spreading of Leukemia Cells, Scientists Find

By Kyle J. Norton

Arnica may have a substantial and sustainable effect in reducing the risk, progression, and treatment of leukemia, some scientists suggested.

The results of these reports were conducted by a number of respectable institutes, including the Chonnam National University and Westfälische Wilhelms-Universität, and published online on the database of medical literature.

Leukemia is a medical condition characterized by cell growth uncontrollable and disorderly produced by the body's blood-forming tissues, including the bone marrow and the lymphatic system. In most cases, it is the result of abnormal white blood cells, which don't function properly.

According to reliable statistics, approximately every 3 minutes one person in the United States (US) is diagnosed with leukemia. New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of 1,735,350 new cancer cases diagnosed in the US in 2018.

The exact causes of leukemia are unknown. However, certain risk factors including smoking, mutation gene inherited from parents such as Down syndrome. blood disorders such as myelodysplastic syndrome are associated with an increased risk of the disease.

Some researchers also suggested that people who have previous treatment for cancer with chemotherapy or radiation are at higher risk of cancer development.

Most common symptoms of leukemia include fever or chills, persistent fatigue and weakness frequent or severe infections due to dysfunction of the immune system caused by immature white blood cells produced.

Some patients may also experience symptoms of unattended weight loss, swelling lymph nodes,... and enlarged liver or spleen.


If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of the skin, tissues, organs, etc.

Leukemia is a chronic condition characterized by high numbers of abnormal white blood cells in the bone marrow.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the investigation of the effect of helenalin, a bioactive chemical compound isolated from Arnica on the human promyelocytic leukemia HL-60 cell line, researchers found that application of the compound exerts a significant effect in induced HL-60 cell differentiation through the expression of granulocytes, white blood cells with secretory granules in its cytoplasm, at a concentration-dependent manner.

Further analysis, injection of helenalin inhibited HL-60 through activating the protein kinase C (PKC) inhibitor with a function to act as ruboxistaurin in signaling molecules that link to multiple cellular processes of cancer.

Moreover, researchers also found that helenalin also inhibits HL-60 proliferation through activating the extracellular signal-regulated kinase (ERK) inhibitors which are used in some cancer therapy in controlling diverse tumor cellular processes such as proliferation, survival, and motility.



Protein kinase C (PKC) is a family of protein kinase enzymes with the function of controlling the expression of other proteins through certain mechanisms.

Additional differentiation also suggested that helenalin induced expression of protein kinase C (PKC) inhibitors without interfering with PKC activity and protein level of PKC beta I and PKC beta II isoforms activities which have been found to promote progression of human cancer.

Interestingly, helenalin also inhibited HL-60 through increasing levels of protein kinase R-like endoplasmic reticulum kinase (PERK) with the function of triggering cancer cell death in a concentration-dependent manner.


Finally, researchers also indicated that the inhibition of HL-60 by helenalin is also carried out through ameliorating levels of NF-kappa, with aberrant activity in enabling leukemia cells to evade apoptosis and stimulate proliferation.

High levels of NF-κB have been detected in most of the patients with acute myeloid leukemia (AML).


These results postulated that helenalin isolated from Arnica inhibits the expression of human promyelocytic leukemia HL-60 cell line through many different pathways involved several aspects in tumor cellular differentiation.

More importantly, in the different aspects of the study, Dr. Dirsch VM and colleagues found that sesquiterpene lactones also exerted a significant cytotoxic effect in triggering leukemia cell apoptosis.

According to cell morphology, four compounds found in sesquiterpene lactones, including ambrosin, alantolactone, hymenin, and helenalin induced apoptosis of Jurkat leukemia T cells, individually, through inducing apoptosis of nuclei and the outer surface of the cell membrane.

Taken together, Arnica and its bioactive sesquiterpene lactones, particularly helenalin may be used to ameliorate the risk, progression, and treatment of Leukemia.

However, additional data collection on large example size and multi-centers studies performed with human consumption of herbal arnica or its' bioactive sesquiterpene lactones during the course of the disease will be necessary to complete the picture of garlic anti-leukemia possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone by Kim SH1, Oh SM, Kim TS. (PubMed)
(2) Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis by Dirsch VM, Stuppner H, Vollmar AM. (PubMed)

Calendula (Calendula officinalis) Together with Eyelid Hygiene Are Effective for Patients with Chronic Blepharitis, According to Studies

By Kyle J. Norton

Herbal Calendula may have a potential effect in reducing the risk and treatment of chronic blepharitis, some scientists suggested.

Blepharitis is a condition caused by the eye inflammation of the eyelids or parts of the eyelids as a result of clogging of tiny oil glands located near the base of the eyelashes, affecting people of all ages.

Blepharitis can be classified into 2 types1. Acute blepharitis is referred to as eyelid infection by bacterial, viral, or parasitic pathogens.

2. Chronic blepharitis or lid inflammation is caused by staphylococcal, seborrheic, and meibomian gland dysfunction (MGD) that lasts more than 3 months.

According to researchers, chronic blepharitis is difficult to treat due to persistently low-grade inflammation.

The most common causes of blepharitis are bacterial infections. However, the condition also can be caused by a skin condition, such as scalp dandruff or rosacea.

If you experience symptoms of itchiness, redness, flaking, and crusting of the eyelids, burning sensation, irritation, tearing, and red eyes, you may have acute blepharitis, please check with your doctor.


Untreated chronic blepharitis can lead to permanent alterations to the eyelid margin or vision loss from superficial keratopathy (abnormality of the cornea), corneal neovascularization, and ulceration.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.


The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.


Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

In the findings of the natural ingredient with potential for the treatment of chronic blepharitis without inducing any adverse effects, Dr. Prozornaia LP and Dr. Brzhevskiĭ VV.launched an investigation to examine the herbal Calendula anti chronic blepharitis activity.

In the total of 110 patients aged from 3 to 42 years old were examined to estimate the efficacy of chronic blepharitis treatment, 50 patients are with chronic blepharitis and dry eye syndrome (DES), 28 are with DES due to computer vision syndrome and 32 are with isolated chronic blepharitis.

All patients received eyelid massage and a complex of hygienic procedures was performed using phytoproducts ("Geltec-Medika", Russia): blepharoshampoo, blepharolotion, blepharogel 1 and 2.

After all the procedures were finished, moist warm pads (with blepharolotion and calendula extraction) were applied on the eyelids in 25 patients.

In comparison to massage, moist warm pads treatment exerts a significant effect in the improved efficacy of background therapy in patients with meibomian gland hypofunction but the insignificant effect in patients with excessive meibomian gland secretion.

These results suggested that Herbal Calendula may be effective in the treatment of chronic blepharitis caused by meibomian gland hypofunction if it is used in conjunction with eyelid hygiene.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) [Efficacy of physiotherapy and hygienic procedures in the treatment of adults and children with chronic blepharitis and dry eye syndrome].[Article in Russian] by Prozornaia LP, Brzhevskiĭ VV.(PubMed)
(2) Interventions for chronic blepharitis by Kristina Lindsley,1 Sueko Matsumura,1 Elham Hatef,2 and Esen K Akpek. (PubMed)