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Monday, 31 August 2020

Tocopherols Inhibits the Onset of Diabetes

By Kyle J. Norton


Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.

The most common symptoms of type 2 diabetes are an increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.

* Latent autoimmune diabetes in adults (LADA), similar to type 1 diabetes, is a slow-progressing form of autoimmune diabetes. The disease is caused by the pancreas inability to produce enough insulin, because of slowly die-off of insulin-producing cells in the pancreas.

LADA is also known as type 1.5 diabetes because the disease has characteristics of both type 1 (autoimmune in nature) and type 2 diabetes.

Therefore, LADA shares the same risk factors and symptoms similar to those types 1 and 2 diabetes.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Hyperglycemia, a hallmark of diabetes has been found to induce diabetics complications, including neuropathy, nephropathy, and retinopathy.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined cross-sectional relations of dietary intakes and plasma concentrations of antioxidants with glucose metabolism in a high-risk population.

The study included the subjects that were 81 male and 101 female first- and second-degree, nondiabetic relatives of patients with type 2 diabetes with Antioxidant intake data that were based on 3-d food records.

According to the analysis of subjects taking supplements containing beta-carotene or alpha-tocopherol
In men, 
* Dietary carotenoids were inversely associated with fasting plasma glucose concentrations (P < 0.05), plasma beta-carotene concentrations were inversely associated with insulin resistance (P = 0.003),

* Dietary lycopene was directly related to baseline serum concentrations of nonesterified fatty acids (P = 0.034).

* In women, dietary alpha-tocopherol and plasma beta-carotene concentrations were inversely and directly associated, respectively, with fasting plasma glucose concentrations (P < 0.05).

In both sexes, cholesterol-adjusted alpha-tocopherol concentrations were directly associated with 2-h plasma glucose concentrations (P < 0.05).

After talking about other factors into account, researchers said, "The data suggest an advantageous association of carotenoids, which are markers of fruit and vegetable intake, with glucose metabolism in men at high risk of type 2 diabetes.".

Taken altogether, tocopherols used alone or combined with beta-carotene may be considered adjunct therapies in the management of diabetes, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study by Ylönen K1, Alfthan G, Groop L, Saloranta C, Aro A, Virtanen SM. (PubMed)

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