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Sunday, 12 July 2020

Common Fig or Fig (Ficus carica), the Potential Anti-Cancer Functional Food

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Cancers are the second leading cause of death worldwide besides heart diseases. 

The most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.

Believe it or not, 1/4 of cancers death are due to lung cancer.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The most common risk factors associated with the onset of cancer age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved the onset of cancer.

However, most people with some of the aforementioned risk factors have never developed cancer.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding natural compounds for the treatment of chronic diseases, researchers examined the potential health-promoting chemical constituents of the fruits of F. Carica anti-inflammatory and anti-proliferative activity.

According to the chemical analysis,
* Four new structurally diverse prenylated isoflavone derivatives, ficucaricones A-D (1-4), along with 12 known analogs (5-16) were separated from the fruits of F. Carica.

* Prenylated isoflavone derivatives (1-16) displayed remarkable inflammatory inhibitory effects against nitric oxide (NO) production with the IC50 values ranging from 0.89 ± 0.05 to 8.49 ± 0.18 μM, comparable to that of the positive control (hydrocortisone).

* All newly discovered compounds 1-16 also exerted pronounced antiproliferative activities against diverse human cancer cell lines in vitro, holding the IC50 values ranging from 0.18 ± 0.03 to 18.76 ± 0.09 μM.

Collectively, researchers said, "the isolation and characterization of these prenylated isoflavone derivatives possessing remarkable anti-inflammatory effects and antiproliferative activities could be meaningful to the discovery of new anti-inflammatory and antitumor agents".

Taken altogether, regular consumption of the fruits of F. carica may prevent the occurrence of inflammatory diseases and tumors, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Inflammatory and Antiproliferative Prenylated Isoflavone Derivatives from the Fruits of Ficus carica by Liu YP1,2,3, Guo JM1,3, Yan G1,3, Zhang MM1,3, Zhang WH1,3, Qiang L2, Fu YH. (PubMed)

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