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Monday 1 June 2020

Green Peas (Pisum Sativum) Inhibits the Risk of Prostate Cancer Through Phytochemical Activity

By Kyle J. Norton


The prostate warped around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.

The prostate gland is considered a reproductive organ in men.

Prostate cancer is a medical condition caused by cell growth disorderly in the prostate tissue due to the alternation of DNA.

At the advanced stage, the cancerous cell in the prostate can spread to the distance away to inject other healthy tissue and organ, leading to a secondary metastasis through lymph and blood.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

The common sites metastases of prostate cancer are bone, lymph nodes, lung, liver.

Researchers do not know the exact causes of prostate cancer. However, they do know the increase in age, family and personal history, ethnicity, genetic preposition, a poor diet, being overweight or obesity are some of the prevalent risk factors of prostate cancer.

According to the Canadian Cancer Society, in 2017, 21,300 men were diagnosed with prostate cancer, represented 21% of all new cancer cases and 4,100 men died from prostate cancer, and 10% of all cancer deaths.

The 5 years survival rate of localized prostate cancer is 100% and 98% of that of survivors are alive after 10 years compared to the advanced stage of only 31%.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of diseases associated with the prostate gland, researchers investigated the flavonoids, found on peas, on the cell cycle progression of human LNCaP prostate cancer cells.

According to the experimental analysis,
* In human LNCaP prostate cancer cells, Genistein, a member in the group of flavonoids, arrested the cell cycle at the G2/M phases, by suppressing cyclin B expression involved in cell cycle division.

* Furthermore, genistein induced the expression cyclin-dependent kinase inhibitor p21, which plays a critical role in the regulation of cell cycle progression at G1 and S phase without depending on the activation of p53.

* Apigenin and luteolin also increased p21 levels, compared to those of quercetin that did not.

Additionally, apigenin induced p21 production through a p53-dependent pathway, but luteolin did so in a p53-independent manner.

Based on the results, scientists said, " flavonoids are potent regulators of cyclin B and p21 for cell cycle progression, which may play some roles in the prevention of carcinogenesis".

Taken altogether, green peas may be considered a functional food for the prevention of prostate cancer,  pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of flavonoids on cell cycle progression in prostate cancer cells by Kobayashi T1, Nakata T, Kuzumaki T. (PubMed)

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