Tocopherols inhibits the Onset of Esophageal Cancer in Vivo

By Kyle J. Norton

The esophagus or gullet, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.

Esophageal cancer is not very uncommon, caused by malignant of the esophagus due to abnormal cell growth as a result of the DNA alternation of the cells that line the upper part of the esophagus or glandular cells that are present at the lower part of the esophagus that connected with the stomach.

Esophageal cancer tends to spread if it left untreated and starts from the lining of the esophagus, then later penetrates the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest, then to the distant parts of the body.

Most common types of esophageal cancer

* Squamous cancer
In the upper part of the esophagus caused by the squamous cell of which has become malignant caused by mutation of DNA in cells replication of division uncontrollably.

* Adenocarcinomas
In the lower part of the esophagus caused by the glandular cells of which have become malignant caused by mutation of DNA in cells replication of division uncontrollably.

According to the statistics provided by the American Cancer Society, in 2019, approximately 17,650 new esophageal cancer cases will be diagnosed, including 13,750 in men and 3,900 in women.

Also, in 2019, esophageal cancer will also cause the death of 16,080 Americans, including 13,020 in men and 3,060 in women.

The 5-year survival rate of people diagnosed in the local stage of esophageal cancer is 45%, much less than other cancer, including 100% of breast cancer.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of dietary tocopherols on esophageal carcinogenesis.

According to the analysis,
* In murine models, dietary tocopherols significantly prevent esophageal cancer by inhibiting the activation of NF-κB, associated with blocking the cancer cell apoptosis and the subsequent interaction of chemokine CXCL9/10/11 with their receptor CXCR3 to prevent ESCC proliferation, angiogenesis, and metastasis.

* Furthermore, dietary supplementation with 0.15% α-tocopherol (α-T), δ-tocopherol (δ-T), or γ-tocopherol rich mixture (γ-TmT) markedly suppressed the production of pro-inflammatory cytokines, as well as the induction of CXCR3+ effector T cells (CD4+ Th1 and CD8+ CTLs) infiltration, at the early stage of carcinogenesis.

In other words, dietary tocopherols significantly that prevent the onset of esophageal cancer In experiments in vivo and in vitro, were tightly correlated with the blockade of NF-κB activation

After talking about other factors into account, researchers said, "tocopherols decrease carcinogenesis through inhibiting NF-κB and CXCR3 signaling, as well as related inflammation in early premalignant lesions. This pathway may offer a novel target for chemoprevention of esophageal cancer".

Taken altogether, tocopherols may be considered a remedy for the prevention of the onset of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocopherols inhibit esophageal carcinogenesis through attenuating NF-κB activation and CXCR3-mediated inflammation by Yang H1, Xu M2, Lu F3, Zhang Q4, Feng Y4, Yang CS5, Li N4, Jia X. (PubMed)