Serum Tocopherols are Inversely Associated with the Risk of Cervical Cancer

By Kyle J. Norton

The cervix is the lower part of the uterus that opens at the top of the vagina.

The cervix acts as a transition area for vaginal lining (squamous epithelium) and uterus (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. 

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

Precervical cancer is the early stage of abnormal cell changes in the cervical tissue.

If left untreated, it can develop into true invasive cervical cancer caused by factors connected to male seminal fluid. A vaccine, Gardasil used to prevent pre-cervical cancer from the infection of two types of HPV was approved by the U.S. Food and Drug Administration in 2006. It is for your benefit to take this vaccine if you are sexually active with several partners.

Types of invasive cervical cancer
* Squamous cell carcinomas
Squamous cells are the thin, flat cells that line the bottom of the cervix.

Abnormal growth of squamous cells accounted for 80 to 90% of invasive cervical cancer. Squamous cell carcinomas are defined as a cancer of which the squamous cells in the cervix have divided and replication in uncontrolled matter due to DNA alternation caused by a virus or other factors.

* Adenocarcinoma
Glandular cells that line the upper portion of the cervix. Abnormal growth of glandular epithelial cells is accounted for 10 to 20 percent of invasive cervical cancers. Adenocarcinoma is defined as cancer of which the glandular epithelium cells in the cervix have divided and replication in uncontrolled matter due to DNA alternation caused by a virus or other factors.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the relationship between serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women.

According to the analysis of the hospital-based case-control study in which 358 adults (158 incident cases and 200 controls) recruited from Xinjiang, China,
* There was an inverse association between serum carotenoid (α-carotene, β-carotene, and lutein/zeaxanthin) and tocopherol (α-tocopherol) concentrations and the risk of cervical cancer after adjusting for potential confounders compared to no effects of the levels of retinol.

* ORs for 1-SD increase were 0.71 (95% CI: 0.56- 0.92; p=0.003) for total carotenoids and 0.75 (95% CI: 0.60-0.94; p=0.008) for total tocopherols.

After talking about other factors into account, researchers said, "These results show that higher serum concentrations of some carotenoids and tocopherols are associated with a lower risk of cervical cancer among Chinese women".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of cervical cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women by Zhang YY1, Lu L, Abliz G, Mijit F. (PubMed)