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Monday, 11 May 2020

Elder (Sambucus) Processes the Natural Immunomodulatory Property

By Kyle J. Norton

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In normal immunity, active immunity may also be artificially acquired caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of immune system against infection through the production of antigen.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

Depending on the substances that affect the immunomodulatory process, some may improve the immune function by modulating the genes involved immune responses and protect the immune system against toxins or immunotoxic effects such as abnormal allergic reactions, other such as heavy metals can induce opposite effects.

For example, curcumin (diferuloylmethane), found in the spice turmeric and processed anti-inflammatory, antioxidant, and chemopreventive activities may improve the immune system in the inhibition of cancer cell proliferation and overproduction of proinflammatory cytokines by target the genes associated with programming cell death and anti-inflammatory action and involved in the induction of these immune parameters.

On the other hand, toxic chemicals such as cadmium and lead accumulated in the body can have a negative impact on the immune defense by reducing the viability of both lymphocytes and macrophages was affected by heavy metals in a dose- and time-dependent manner.

On finding a natural ingredient for the improvement of immune functioning, scientists examined the immunomodulatory effects of bioactive compounds of Sambucus.

Elder or Common Elder, is a shrub or small tree of the genus Sambucus of 30 species, belonging to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere.

The herb has been used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.

According to tested analysis from orally administrated with 2.8 mg.kg-1 BW of DMBA for ten times within a month with 7,12-dimethylbenz[a] anthracene (DMBA)-treated BALB/c mouse, followed by S. javanica berries and leaves extracts for 2 weeks.

* The expression of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-ɣ) associated with the induction of inflammation were increased however after treated by S. javanica berries compared to that of leaves extracts that were significantly decreased.

* Furthermore, the DMBA-treated group showed an increase of necrosis incidence.

* Moreover, These increased was totally diminished with S. javanica extracts treatment.

Based on the results, researchers suggest, " these results suggested that S. javanica extracts have immunomodulatory activities to suppress inflammation and reduce necrosis incidence in experimental mice".

Taken altogether, Dandelion may be considered a remedy for the treatment of acute liver injury, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory Activities of Sambucus javanica Extracts in DMBA-Exposed BALB/c Mouse by Putra WE1, Rifa'i M. (PubMed)

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