Platelet aggregation is a condition of platelets clumping together in the blood. In most cases, the process is to protect the vascular injury against additional bleeding and microbial pathogenic invasion.
In other words, platelet aggregation is stimulated by the first-line immune response after sensing bodily injury or damage accompanied by the production of pro-inflammatory cytokines to defend
the injured area against infection.
Platelet disorders can lead to abnormal bleeding. Most common types of genetic proposition of platelet disorders including disorder of platelet adhesion, aggregation, secretion, and procoagulant activity.
If your blood platelet count falls below the normal range from 150,000 to 450,000 platelets per microliter of circulating blood, you are considered thrombocytopenia.
Most common symptoms of platelet disorders are unexplained bruising throughout the body, bleeding from your nose, mouth, or gums, under your skin, muscles, and joints and heavy or prolonged menstrual bleeding,
In severe cases, patients may also experience symptoms of vomiting blood, blood in your feces and internal bleeding.
Conventionally, most common medication with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
On finding a potent ingredient for the treatment of heart disease, scientists compared the antiplatelet effect of lycopene with aspirin.
In vitro, various concentrations of Aspirin (140 μmol/L) and lycopene (4, 6, 8, 10, and 12 μmol/L) were studied against adenosine-5'- diphosphate (ADP) (2.5 μM/L) and collagen.
Based on the tested analysis, all concentrations of lycopene (4-12 μmol/L) exhibited a reduction of maximum platelet aggregation induced by aggregating agents ADP and collagen comparable with aspirin.
However, all 4 μmol/L of lycopene combined with 140 μmol/L and 70 μmol/L aspirin showed greater inhibition of platelets compared to aspirin 140 μmol/L alone, against both ADP and collagen.
In severe cases, patients may also experience symptoms of vomiting blood, blood in your feces and internal bleeding.
Conventionally, most common medication with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
On finding a potent ingredient for the treatment of heart disease, scientists compared the antiplatelet effect of lycopene with aspirin.
In vitro, various concentrations of Aspirin (140 μmol/L) and lycopene (4, 6, 8, 10, and 12 μmol/L) were studied against adenosine-5'- diphosphate (ADP) (2.5 μM/L) and collagen.
Furthermore, lycopene at concentration 10 μmol/L showed a maximum platelet inhibition (47.05%) of ADP, whereas lycopene at concentration 8 μmol/L showed maximum platelet inhibition (54.26%) of collagen.
In other words, lycopene protects the cardio function selectively and dose-dependently.
Based on the findings, researchers said, "The study favorably compares lycopene and aspirin with respect to their antiplatelet activities against ADP and collagen" and "Lycopene can be considered as a potential target for modifying the thrombotic and pro-inflammatory events associated with platelet activation".
Taken altogether, lycopene found in tomato may be considered an anti-platelet aggresion phytochemical, pending on the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study by Sawardekar SB1, Patel TC1, Uchil D. (PubMed)
(2) Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation by Hsiao G1, Wang Y, Tzu NH, Fong TH, Shen MY, Lin KH, Chou DS, Sheu JR. (PubMed)
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study by Sawardekar SB1, Patel TC1, Uchil D. (PubMed)
(2) Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation by Hsiao G1, Wang Y, Tzu NH, Fong TH, Shen MY, Lin KH, Chou DS, Sheu JR. (PubMed)
No comments:
Post a Comment