Angelica Sinensis Destroys the Glioma Cells in Vitro and in Vivo

By Kyle J. Norton

A glioma is a type of brain and spinal cord tumor characterized by the alternation of DNA of the glial cells.

Believe it or not, gliomas have been found accounting for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.

Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.

* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.

* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.

Primary glioblastoma is considered the most aggressive cancer that begins within the brain. Cancer may arise de novo, meaning they begin as a Grade IV tumor with no evidence.

According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.

Due to the rapid growth of the tumor, patients diagnosed with primary glioblastoma experience brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, and severe headaches and localized symptoms depending on the location of the tumor.

Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.

On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the inhibitory effects of Angelica polysaccharides (APs), bioactive constituents of Angelica on a glioma cell line.

Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis both in vitro and in vivo models,
* APs exerted a significant inhibition of the growth and proliferation of U251 cells and induced their apoptosis.

* APs effectively reduced the expression of several cell cycle regulators such as cyclins D1, B, and E in the induction of cell cycle division of the tested cell line.

* APs also inhibited the anti-apoptotic protein Bcl-2 and increased the expression of pro-apoptotic proteins Bax and cleaved-caspase-3.

* Most importantly, APs inhibited the transforming growth factor (TGF)-β signaling pathway and stimulated the expression of E-cadherin, associated with the inhibition of cell growth.

Based on the results, researchers suggest, " the results indicate that APs attenuate the tumorigenicity of glioma cells and promote their apoptosis by suppressing the TGF-β signaling pathway".

Taken altogether, Dandelion may be considered a neuroprotective remedy, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo by Zhang WF1, Yang Y1, Li X1, Xu DY1, Yan YL1, Gao Q1, Jia AL1, Duan MH. (PubMed)