Turmeric Protects the Cells integrity Against Cancer In Vitro

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of cancer with no side effects, according to studies.

Cancer is a class of medical diseases caused by the alternation of cell DNA.

Most cases of primary cancer begin in the cells on the surface of the inner lining of tissues. However, at the later stage, the malignant cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through blood and fluids circulation.

The 5 years survival of early diagnosed cancer are high, some of them have a statistic of 100% such as breast cancer. However, the actual 5-year survival rate is totally depending on the types of cancer.

According to the statistics provided by the National Cancer Institute, in the US, 1,735,350 new cases of cancer were diagnosed and the disease causes the death of 609,640 people in 2018.

The most common cancer in the US, 2018 are breast cancer followed by lung and bronchus cancer, prostate cancer, colon and rectum cancer.

Believe it or not, over 1/3 of men and women will be diagnosed with cancer at some point during their lifetimes.

Most cancers share the common symptoms of gastrointestinal discomforts, such as nausea vomiting,  fatigue unintended weight loss and loss of appetite accompanied by specific symptoms depending on the types and grade of cancer.

The exact causes of cancer are not identified. However, according to the epidemiological studies most common risk factors associated with cancer onset are aging, lifestyle, family history, and race.

Some researchers suggested that the introduction of Western diet over the past few decades may be one of the major factors that cause the rises of cancer.

The Global News in the examined the risk of cancer in people who follow the Western diet wrote, "Published in the journal JAMA Oncology, the study followed more than 120,000 adults over 26 years and found that inflammation is a potential link between diet and cancer development. Researchers found a 44-per-cent risk increase for men, and 22-per-cent for women who consumed a pro-inflammatory diet (even after adjusting for other factors, such as high body mass index and decreased physical activity)".

In other words, the risk of cancer is many folds higher in people who follow the long-term Western diet.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a natural compound for the treatment of cancer with no side effects, researchers evaluated the anticancer activity of Curcuma caesia Roxb. (Black turmeric), used as a spice, food preservative and coloring agent commonly in the Indian subcontinent.

According to the total antioxidant activity (TAO) method, among all the extracts of dried C. caesia rhizome viz- hexane, ethyl acetate, methanol and water, hexane Rhizome Extract (HRE) was found to possess remarkable antioxidant activity (1200mg ascorbic acid equivalent/100g) compared to other extracts.

In MTT assay, HRE exhibited a dose-dependent inhibition of cancer cells, with notable activity in HepG2 cell lines (IC50: 0976µg/mL).

In Western blotting and flow cytometry assay, HRE induces cell arrest at the G2/M phase along with cellular apoptosis by stimulating the production of a protein associated with cell death programming.

According to the analysis of Gas Chromatography-Mass Spectrophotometry (GC-MS) assays, the anti-cancer cells efficacy of hexane Rhizome Extract (HRE) was attributed to over 20 compounds that inhibit the mutation of epidermal growth factor receptor EGFR (1XKK) in the induction of cancer.

Dr. Mukunthan KS, the lead scientist said, " Our results provided significant evidence of the toxicity mechanisms of HRE that may be beneficial for more rational applications of drug discovery for slowing down cancer progression".

Taken altogether, turmeric may be considered a supplement for the prevention and treatment of cancer with on side effects, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Liposomal curcumin and its application in cancer by Feng T#1, Wei Y#1, Lee RJ2, Zhao L. (PubMed)
(2) Pharmacological evaluation of phytochemicals from South Indian Black Turmeric (Curcuma caesia Roxb.) to target cancer apoptosis by Mukunthan KS1, Satyan RS2, Patel TN. (PubMed)
(3) Study finds Western diet increases risk of cancer, especially in women by By Global News