Pancreatin, the Mixture that Improves the Absorption of Fat, Protein, and Energy In Patients with Pancreatic Insufficiency

By Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, a vital organ is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.

More precisely, the functions of the pancreas including

* Production of enzymes digest fat, protein, and
carbohydrates.

* production of juices combined with juices from the intestines helps to do the job of breaking down protein, carbohydrates and fat, therefore, it plays an important role in maintaining good health.

*  Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic insufficiency is a medical condition in which the pancreas is not able to produce and/or transport enough digestive enzymes to break down food in the intestine.

Two of the most common causes of pancreatic insufficiency (EPI) are cystic fibrosis and chronic pancreatitis.

Other diseases associated with the condition are irritable bowel syndrome (IBS), peptic ulcer disease, gallbladder diseases, and inflammatory bowel problems.

Conventionally, depending on the severity of pancreatic insufficiency, the main treatment is to replace the levels of a pancreatic enzyme using pancreatic enzyme replacement therapy, or PERT.

 Pancreatin, are commercial mixtures of amylase, lipase, and protease.
On finding a potential phytochemical for the prevention and treatment of pancreatic diseases, researchers elucidated the effects of neutral sterols and short-chain fatty acids on high-lipase pancreatin in Japanese patients with pancreatic insufficiency whose dietary fat consumption is low.

The study included 15 patients with chronic pancreatitis complicated by steatorrhea who consumed an average of 48 g of dietary fats a day were given 3 g of high-lipase pancreatin (lipase, 379,800 USP U/g), at each meal (the total daily dose is 9 g) for a mean duration of 28.5 days.

According to the fecal output and fecal fat neutral sterol, bile acid, and short-chain fatty acid excretion analysis,

* Pancreatin administration resulted in significant reductions (P < 0.01) in fecal output (from 243.2 to 149.1 g), excretion of fecal fat,

* Furthermore, animal sterols (from 816.3 to 604.6 mg), and short-chain fatty acids were reduced (from 12.3 to 3.9 g), and (from 52.6 to 18.5 mM), respectively.

Interestingly, the administration of pancreatin showed no marked changes in fecal excretion of beta-sitosterol (a plant sterol), bile acids, or the hydroxy fatty acid fraction.

In other words, Pancreatin improved patients with pancreatic insufficiency to absorb fat, protein, and energy.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of obesity-related chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of high-lipase pancreatin on fecal fat, neutral sterol, bile acid, and short-chain fatty acid excretion in patients with pancreatic insufficiency resulting from chronic pancreatitis by Nakamura T1, Tandoh Y, Terada A, Yamada N, Watanabe T, Kaji A, Imamura K, Kikuchi H, Suda T. (PubMed)