Lycopene Promotes Multitargeted Therapy of Cancer

By Kyle J. Norton

Cancer is the class of diseases associated with cell growth disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Multitargeted therapy of cancer treatment, in general, to induce an imbalance between cell survival and apoptosis through interference by enhancing the cell cycle regulators and proteins involved in apoptosis. 

Dr. Mehta K, the lead scientist in the joint study led by The University of Texas MD Anderson Cancer Center, wrote, "The Society of Translational Cancer Research held its biennial meeting in the capital city of India, Delhi from February 6th through 9th, 2014 to discuss 'Multi-targeted Approach to Treatment of Cancer'"

And "Talks were presented by leaders in the cancer research field from various countries. It became clear from this conference that coupling multiple targeted-agents or using an agent that hits an individual target in several independent locations in the disease-causing pathway(s) may be the best approach to treat different cancers".

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of cancer, researchers examined the role of lycopene (L)  as a multitargeted therapy of cancer.

In vitro, lycopene exerted many mechanisms of chemoprevention, including the induction of apoptosis and antiproliferation in cancer cells, anti-metastatic activity.

Furthermore, lycopene also enhanced and promoted an antioxidant response in the synthesis of cytoprotective enzymes.

Moreover, lycopene, a substrate for carotene-9',10'-monooxygenase (CMO2) and can be converted to apo-10'-carotenal plays a critical to inhibit cancer cell migration and angiogenesis.

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Multitargeted therapy of cancer by lycopene by van Breemen RB1, Pajkovic N. (PubMed)
(2) Multi-targeted approach to cancer treatment: an international translational cancer research symposium by Mehta K1, Gandhi V2, Pathak S3, Aggarwal BB2, Grover RK. (PubMed)