Fish Oils Process a Positive Effect on Plasma Lipids in Healthy Individuals

By Kyle J. Norton

Lipid refers to cholesterol and triglycerides.

Hypertriglyceridemia is a health issue associated with abnormally high blood levels triglycerides,
Triglycerides are body fat found in humans derived from glycerol and saturated, monounsaturated, and polyunsaturated fatty acid.

The triglycerides are stored in your fat cells to energy in the future when the body's needs.
if the levels of triglycerides are above 500 mg/dL (above 5.7 mmol/L), you have high blood triglyceride.

Abnormal high levels of triglycerides have been found to induce symptoms of gastrointestinal pain. difficulty breathing, memory loss, dementia and yellowish deposits of fat on or around the eyelids.

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

Cholesterol produced by the liver and absorbed through diet to build cell walls, produce steroid hormone and vitamin D and aid digestive, the primary of triglycerides function is to store as unused calories and provide your body with energy.

The healthy ratio of low-density lipoprotein (LDL)/high-density lipoprotein (HDL) is ant numbers that are less than 4.

Fish oil derived from the tissues of fishes, containing a high amount of the omega-3 fatty acids.
The three main components of omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of chronic disease, researchers launch a first-in-human trial of LCMUFA-rich saury fish oil supplementation effect on plasma lipids.

The double-blind, randomized, crossover clinical trial included 30 healthy normolipidemic adults (BMI <25 kg/m2; mean TG, 84 mg/dL) who were treated by either 12 g of sauredy oil (3.5 g of LCMUFA and 3.4 g of omega-3 FAs) or identical capsules with control oil (a mixture of sardine and olive oil; 4.9 g of shorter-chain MUFA oleate and 3 g of omega-3 FAs).

According to the results, saury oil supplementation was safe and resulted in LDL particle counts 12% lower than control oil.

On a linear mixed effect model, saury oil also showed a minor effect on increasing HDL particle size (9.8 nm vs 9.7 nm; P < .05), compared to the control oil which increased LDL-C by only 7.5% compared with baseline.

Most importantly, saury oil exerted similar effects compared to  control oil on lowering plasma TG levels, VLDL, and TG-rich lipoprotein particle counts (by ∼16%, 25%, and 35%, respectively; P < .05), and increasing HDL-C and cholesterol efflux capacity (by ∼6% and 8%, respectively; P < .05) compared with baseline.

Based on the findings, researchers said, "Saury oil supplementation is well tolerated and has beneficial effects on several cardiovascular parameters, such as LDL particle counts, HDL particle size, and plasma TG levels".

Taken altogether, fish oil may be considered a functional food for the protection of cardiovascular parameters, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Supplementation with saury oil, a fish oil high in omega-11 monounsaturated fattyacids, improves plasma lipids in healthy subjects by Yang ZH1, Amar M2, Sorokin AV2, Troendle J3, Courville AB4, Sampson M5, Playford MP6, Yang S4, Stagliano M2, Ling C5, Donkor K2, Shamburek RD2, Mehta NN6, Remaley AT. (PubMed)

hypertriglyceridemia
(1) Recent developments in pharmacotherapy for hypertriglyceridemia: what's the current state of the art? by Florentin M1, Kostapanos MS2, Anagnostis P3, Liamis G. (PubMed)