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Wednesday 26 February 2020

Cranberry, a Natural Gingipain Inhibitor

By Kyle J. Norton

Periodontitis is a severe stage of gingivitis that damages the soft tissue and destroys the bone that supports your teeth, leading to teeth loosen or tooth loss.

Systemic diseases are a group of condition that affects other parts of the body, or even the whole body.

The most common symptomatic disorders are high blood pressure that affects the brain and diseases associated with the circulatory system or systemic disease flu that affects the entire body.

An infection in the bloodstream is called a systemic infection.

Most common systemic diseases are
* Rheumatoid arthritis 
Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1). According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions. 

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation. 

 * Atherosclerosis
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

* Sickle cell anemia
Sickle cell anemia (SCD), a genetic preposition form of anemia is a condition associated with not enough healthy red blood cells to carry adequate oxygen throughout your body.

The red blood cells in sickle cell anemia patines are rigid and sticky with the shapes of sickles or crescent moons.

The normal red blood cells live for about 120 days compared to the sickle cells that die in 10 to 20 days. In other words, the inability of the body to replace the cell that dies rapidly with new blood cells is a cause of sickle cell anemia. 

Other systemic diseases may include diseases of the heart, malignant neoplasms, cerebrovascular diseases, chronic obstructive pulmonary disease, pneumonia, influenza, diabetes mellitus, trauma, Alzheimer's disease, renal diseases, septicemia, and liver diseases.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases that affect part or whole body, researchers investigated the cranberry and rice extracts effect on gingipains associated with
periodontitis and systemic diseases.

According to the tested results, the administration of cranberry and rice extracts interfere with gingipain activity and prevent the growth and biofilm formation of periodontopathogens.

In other words, the tested extract showed a gingipain inhibition that represents a novel approach to treat and prevent periodontitis. 

The cranberry rice extract as a gingipain inhibitor may also help treat systemic disorders that are associated with periodontitis, including cardiovascular disease, rheumatoid arthritis, aspiration pneumonia, pre-term birth, and low birth weight.

Taken altogether, cranberry combined with other herbal medicine may be considered a remedy for the treatment of systemic diseases in patients with periodontitis, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)
(2) The Holistic Prevention, Management and Treatment of Rheumatoid Arthritis back by Research and Studies of Renowned Institutions by Kyle J. Norton

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