Common Fig or Fig (Ficus carica) Processes Anti-Nephrotoxicity in Vivo

By Kyle J. Norton

The kidneys are essential bean shape organ of our body, located just below the rib cage, one on each side of your spine.

Kidneys play a critical role in filtering blood with billions of glomeruli by separating the cells of blood from plasma and reabsorb back substances, and secret waste such as urea and ammonium are stored into pelvis then into the ureter to the bladder.

Furthermore, kidneys also process the functions that regulate electrolytes, blood pressure, maintains acid-base balance, produce hormone calcitriol, renin, and erythropoietin, etc.

Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.

The disease is caused by a poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.

According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.

And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.

The most common symptoms of nephrotoxicity are associated with kidney dysfunction, including increased urine output, although occasionally urine output remains normal, fluid retention, swelling in your legs, ankles or feet, fatigue, nausea, and weakness.

In severe cases, patients may also experience symptoms of shortness of breath (lung), confusion (brain) and irregular heartbeat (heart).

Fig is a species of F. carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding a natural whole food for the treatment of kidney diseases, researchers examined the effects of Ficus carica L. (Anjir) leaf extract on renal oxidative stress induced by gentamicin in albino mice.

The 8 days study included 30 mice that were divided into three groups, containing 10 mice each.
* Group A being the control

* Groups B were experimental and treated with gentamicin 200 mg/kg/day intraperitoneally and,

* Group C was treated by Ficus carica L. leaf extract 400 mg/kg/day orally with gentamicin 200 mg/kg/day intraperitoneally.

According to the tested differentiation,
* Gentamicin treatment group showed increased serum urea and creatinine levels an indication of kidney damage or kidney toxicity.

* Group treated by Ficus carica L. leaf extract showed a significant reduction in biochemical markers of kidney functions, compared to group B and control.

* According to the histopathological examination, group A showed normal renal structure which was deranged in group B treated with only gentamicin, compared to group C which exhibited marked improvement in histological structure.

Based on the results, researchers wrote, "Ficus carica L. leaf extract is effective in preventing gentamicin-induced functional and structural changes in kidney of albino mice.

Taken altogether, common fig processed abundantly anthocyanin may be considered a natural anti-oxidative stress-induced kidney toxicity, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) THE EFFECT OF FICUS CARICA L. (ANJIR) LEAF EXTRACT ON GENTAMICIN INDUCED NEPHROTOXICITY IN ADULT MALE ALBINO MICE by Ghaffar A, Tahir M, Lone KP, Faisal B, Latif W. (PubMed)