Ursolic Acid, A Potential Adjunct Therapy for the Treatment of Lung Cancer

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue.

A most common form of primary lung cancer is derived from epithelial cells. In the Us, Lung cancer causes the death of  158,683 people, including 88,329 men and 70,354 women, according to the 2007 statistic.

Believe it or not, each year, more people die of lung cancer than of colon, breast, and prostate cancers combined.

Most people diagnosed with lung cancer are 65 or older, compared to a very small number of those younger than 45.

Non-small cell lung cancer is the most common type of lung cancer. It usually grows and spreads methodically and predictably. 

Most common types of lung cancers include

* Squamous-cell carcinoma is a type of NSCLC often found in an outer area of the lung.

* Large-cell carcinoma is a type of NSCLC found in the center of the lung by an air tube.

* Adenocarcinoma is a type of NSCLC found in any part of the lung.

The 5 years of the survival rate of never and ever smokers in patients with stage I is 92%, compared to 76%, in smokers.

The 5-year recurrence-free proportions (RFPs) for never and ever smokers were 89% compared to 80%, in smokers.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of ursolic acid (UA) on the stemness of non-small cell lung cancer (NSCLC) cells.

According to the analysis of the NSCLC cells with paclitaxel resistance (A549-PR) which exhibited a remarkably stronger stemness than the parental A549 cells,

* UA administration significantly reduced the stemness and paclitaxel resistance of A549-PR cells.

* UA inhibited the miR-149-5p/MyD88 signaling in the promotion of cancer cell resistance and responsible for UA-mediated effects on the stemness of A549-PR cells.

After talking about other factors into account, researchers said, "UA could attenuate the stemness and chemoresistance of NSCLC cells through targeting miR-149-5p/MyD88 axis".

Taken altogether, Ursolic acid may be considered adjunct therapies in the treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells by Chen Q1, Luo J1, Wu C1, Lu H1, Cai S1, Bao C1, Liu D1, Kong J. (PubMed)