Turmeric Kills Non-Small Cell Lung Cancer Cells In Vitro

By Kyle J. Norton

Cancer is a class of medical and chronic diseases caused by irregular cell growth due to the alternation of cell DNA in the tissue of a specific organ.

Cancer cell that grows and multiplies disorderly and uncontrollably over time can induce the forming of tumor after penetrating into deeper layers of the infected organ tissue.

At the advanced stage, most invasive tumors can travel a distance away to infect other organs in the body via lymph or blood.

The lung is a vital organ located near the backbone on either side of the heart with functions of inhaling oxygen from the air before passing them to other parts of the body and exhaling carbon dioxide from the bloodstream.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells.

According to the statistics provided by the American Cancer Society, lung cancer is by far the leading cause of cancer death among both men and women in the US. Believe it or not, each year, more people die of lung cancer than of colon, breast, and prostate cancers combined.

Most people diagnosed with lung cancer are 65 or older, compared to a very small number of those younger than 45.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, that usually grows and spreads methodically and predictably including
* Squamous-cell carcinoma is a type of NSCLC often found in an outer area of the lung.

* Large-cell carcinoma is a type of NSCLC found in the center of the lung by an air tube.

* Adenocarcinoma is types of NSCLC found in any part of the lung.

Dr. Paris D. Makrantonakis, the lead scientist in examined the correlation of NSCLC risk and treatment in elderly wrote, "The population is aging both in developing and developed countries. What is clear is that currently, over 50% of all patients with non-small cell lung cancer (NSCLC) are 65 years of age or older".

And, "recently published studies have focused on the issue and have provided strong evidence of improved progression-free survival, overall survival, and quality of life in elderly patients with appropriately treated NSCLC".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of non-small cell lung cancer (NSCLC), researchers examined the effect of curcumin on the expression of adiponectin in paired tumors and normal lung tissues from 77 patients with NSCLC.

Epidemiologically, patients with low adiponectin expression ratio (<1) were found to have significantly longer survival time compared to those with high expression ratio and adiponectin may be a prognostic indicator of NSCLC.

Administration of curcumin showed to inhibit the migratory and invasive ability of A549 cells by inhibiting the adiponectin expression. 

Furthermore, Curcumin treatment also inhibited the in vivo tumor growth of A549 cells associated with the adiponectin expression.

More precisely, the efficacy of curcumin that inhibits the NSCLC was attributed to the mediation of pathways involving in promoting tumor invasion.

Additionally, according to the Shanxi Province Tumor Hospital study, curcumin inhibited the A549 cells proliferation also was found by decreasing intracellular ROS levels and increasing SOD and gamma-glutamylcysteine synthetase (γ-GCS) activity passcode with cancer cells apoptosis.

The results strongly suggested that curcumin-induced reduction of A549 viability. by inhibiting the expression of oxidative stress.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway by Tsai JR1,2, Liu PL1, Chen YH3, Chou SH1,4, Cheng YJ5, Hwang JJ1,2, Chong IW. (PubMed)
(2) Curcumin inhibits the growth via Wnt/β-catenin pathway in non-small-cell lung cancer cells by Wang JY1, Wang X, Wang XJ, Zheng BZ, Wang Y, Wang X, Liang B. (PubMed)
(3) Non-Small Cell Lung Cancer in the Elderly by Paris D. Makrantonakis, Eleni Galani, and Peter G. Harper. (The Oncologist)