The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.
The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linked to increased mortality, extending to those with chronic liver disease.
Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.
Hepatotoxicity is a condition caused by the accumulation of toxins in the liver, leading to liver dysfunction or reduced liver function.
Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.
Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long-term use of certain medicines.
Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.
Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long-term use of certain medicines.
There are many causes associated with liver toxicity including chemical toxins, which normally induce acute liver toxicity, such as those used in laboratories and industries, natural chemicals, and long-term use of certain medication.
The most common signs and symptoms of liver toxicity include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.
From the liver perspective, the extracts decreased the levels of AST, ALT, and hydroxyproline levels involved in liver oxidative stress and the rate of liver fibrosis rates.
Hepatopathic rats treated with 70% EtOH and MeOH extracts of the seed showed a higher retinoid level compared to water-treated control rats.
Based on the findings researchers suggested, " the positive effect on liver function of the extracts varies depending on the extracting solvent used. 70% EtOH and MeOH extract of the seeds inhibited the development of liver fibrosis in hepatopathy rats, thus exhibiting potent improvement".
Beta-Sitosterol is a phytochemical in the class of phytosterols, belongings to the group of lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the pharmacological efficacy of the seed extracts, constituents of the seeds including unsaturated fatty acids linolenic and linoleic acids, and the sterol beta-sitosterol in the 70% EtOH and the MeOH extracts.
According to the chemical analysis, in rat experiment, the seed extracts orally administered attenuated the dimethylnitrosamine-induced hepatopathy, and blood L-aspartate aminotransferase (AST) and L-alanine aminotransferase (ALT) levels, liver retinoid level, and hydroxyproline level.On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the pharmacological efficacy of the seed extracts, constituents of the seeds including unsaturated fatty acids linolenic and linoleic acids, and the sterol beta-sitosterol in the 70% EtOH and the MeOH extracts.
And, " The unsaturated linolenic and linoleic acids and the sterol beta-sitosterol contained in these extracts may also contribute to the improvement of liver function".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of liver toxicity pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of extract derived from Eriobotrya japonica on liver function improvement in rats by Nishioka Y1, Yoshioka S, Kusunose M, Cui T, Hamada A, Ono M, Miyamura M, Kyotani S. (PubMed)
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of extract derived from Eriobotrya japonica on liver function improvement in rats by Nishioka Y1, Yoshioka S, Kusunose M, Cui T, Hamada A, Ono M, Miyamura M, Kyotani S. (PubMed)
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