Tocopherols Promote Cytotoxic Activity Against Cancer Cells

By Kyle J. Norton


Cytotoxicity is the process that induces cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy the living cells.

In normal, cytotoxicity can cause the death of healthy cells

In cancers, cytotoxicity can be beneficial to humans by destroying the cancer cells and preventing them from proliferation.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

However, stimulation of ROS expression to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

Scientifically, most cases of cancer cell cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.

Chemotherapy is a type of cancer treatment that uses one or more toxic chemicals to kill cancer cells.

Chemotherapeutic cytotoxicity is the process that interferes with cell division (mitosis) through cell cycle arrest to include apoptosis.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancer researchers examined protective effects of α- and γ-tocopherols and α- and γ-tocotrienols on the oxidative stress induced by LPS on human lung carcinoma A549 cells.

Application of α- and γ-tocopherols and α- and γ-tocotrienols showed strong suppression of the intracellular reactive oxygen formation, lipid peroxidation, and induction of inflammatory mediator cytokines, and cell death.

More precisely, the application of tocopherols incorporated into cultured cells could suppress LPS-induced oxidative stress at much lower intracellular concentration than tocotrienols compared to the much slower tocotrienols.

In other words, tocopherols demonstrated the strongest cytotoxicity against the tested cancer cells compared to that of tocotrienols.

Collectively, researchers wrote, "α-tocopherol may exhibit the highest protective capacity among the vitamin E isoforms against LPS-induced oxidative stress".

Taken altogether, tocopherols may process cytotoxicity against the onset of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols by Nishio K1, Horie M, Akazawa Y, Shichiri M, Iwahashi H, Hagihara Y, Yoshida Y, Niki E. (PubMed)