Phytochemical Tocopherols Process Anti-Inflammatory Property

By Kyle J. Norton

Anti-inflammatory activity is the use of a substance or treatment for the treatment of od inflammation or swelling.

Anti-inflammatory protein in the body displays anti-inflammatory properties against the risk of autoimmune diseases and immune pathologies such as rheumatoid arthritis, psoriasis or organ rejection.

Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.

After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.

In this acute phase of the battle, most of the time is won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead to the death of nearby healthy cells and improper skin healing with the formation of scars.

In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.

Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.

Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.

In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of diseases associated with inflammation, researchers examined the effects of γ-tocopherol (γT), δ-tocopherol, and γ-tocotrienol antioxidant and anti-inflammatory properties.

According to the tested analysis, γ-tocopherol (γT), δ-tocopherol, and γ-tocotrienol showed strong activity in scavenging reactive nitrogen species, inhibiting the enzymes associated with the mediation of the pro-inflammatory cytokines such as cyclooxygenase- and 5-lipoxygenase-catalyzed eicosanoids.

Furthermore, the phytochemicals also suppressed the proteins involving in proinflammatory signalings such as NF-κB and STAT3/6.

Moreover, the side-chain ω-oxidation involved in oxidative stress was also inhibited by the application.

In Vivo, long-chain carboxychromanols, especially 13'-carboxychromanols found in the phytochemicals exerted a strong anti-inflammatory activity in the study.

Based on the findings, researchers said, " in Vivo and Vitro, γT and tocotrienols may be useful against inflammation-associated diseases".

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of diseases associated with acute and chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatoryactivities and their role in disease prevention and therapy by Jiang Q. (PubMed)