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Tuesday, 31 January 2023

Phytochemical Beta-Sitosterol Processes Anti-Hyperglycemia and Anti-Diabetes Activity

By Kyle J. Norton

Diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Latent autoimmune diabetes in adults (LADA), similar to type 1 diabetes, is a slow-progressing form of autoimmune diabetes. The disease is caused by the pancreas' inability to produce enough insulin, because of slowly die-off of insulin-producing cells in the pancreas.

LADA is also known as type 1.5 diabetes because the disease has characteristics of both type 1 (autoimmune in nature) and type 2 diabetes.

Unlike type 2 diabetes, patients with LADA do not respond well to seems to lifestyle and medication as in type-2 diabetes in the long term. Medicine used for the treatment of type 2 diabetes does not halt or slow the progression of loss of pancreas beta cells.
 Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Although hyperglycemia is a hallmark in patients with diabetes, the condition can also occur in people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly and can be controlled by the following diabetes guidance. 

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention of diseases involved in high blood sugar, researchers evaluated the antioxidant potential of β-sitosterol (BS), a phytosterol from Solanum surat-tense, using an experimental model for diabetes-induced oxidative damage.

According to the results from the study of 21 days of treatment with BS (10, 15, and 20 mg/kg, p.o.) on blood, serum, in control and streptozotocin-induced diabetic rats that were divided into 9 experimental groups, including a control group, a diabetic group, and BS- and glibenclamide-treated diabetic groups.

All application doses dependently showed a decrease of glycated hemoglobin, serum glucose, and nitric oxide, with concomitant increases in serum insulin levels.

In other words, β-sitosterol (BS), exerted anti-hyperglycemic activity to protect the diabetics against complications caused by improper management of high blood glucose in a dose depending manner.

Moreover, treatment with BS doses also increased pancreatic antioxidant levels against the pancreatic oxidative stress-induced the death of beta cells with a concomitant decrease in thiobarbituric acid-reactive substances.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of diabetes, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia by Gupta R1, Sharma AK, Dobhal MP, Sharma MC, Gupta RS. (PubMed)

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