Pages

Monday 13 September 2021

Healthy Food Broccoli's Sulforaphane Gobbles Up Gastric Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.

The stomach formed part of the digestive system located between the esophagus and the small intestine, is a muscular, hollow and an important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Stomach cancer is a condition of abnormal growth of the mucus-producing cells in the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man lifetime is about 1 in 95.

The exact causes of gastric/stomach cancer are unidentified. However, researchers do no certain risk factors are associated with an increased risk of the disease.

Some researchers suggested that people with chronic gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease.

Other diseases associated with the early onset of gastric cancer are obesity and smoking.

According to the Universidad de Salamanca, bacteria and viruses, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential phytochemical for the treatment of cancer, researchers examined the inhibitory effect of sulforaphane (SFN), the major component extracted from broccoli/broccoli sprouts on gastric cancer.

According to the tested analysis, in vitro, the tumorsphere formation associated with tumor progression and recurrence and the expression levels of gastric cancer stem cells (CSCs) markers were significantly decreased by the SFN treatment.

Furthermore, SFN exerted strong inhibitory effects by suppressing proliferation and inducing apoptosis in gastric CSCs.

Moreover, SFN inhibited the activation of Sonic Hh, a key pathway in maintaining the stemness of gastric CSCs.

Based on the findings, researchers said, "these data revealed that SFN could be a potent natural compound targeting gastric CSCs via suppression of Sonic Hh pathway, which might be a promising agent for gastric cancer intervention".

Taken altogether, broccoli processed a high amount of SFN may be considered a functional food for the prevention and treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway by Ge M1, Zhang L1, Cao L1, Xie C2, Li X2, Li Y2, Meng Y2, Chen Y2, Wang X2, Chen J2, Zhang Q2, Shao J1, Zhong C. (PubMed)

No comments:

Post a Comment