Green bean Processes Antiplatelet Activity Against the Risk Of CVD

By Kyle J. Norton

Platelet aggregation is a condition of platelets clumping together in the blood. In most cases, the process is to protect the vascular injury against bleeding and microbial pathogenic invasion.

In other words, platelet aggregation is stimulated by the first-line immune response after sensing bodily injury or damage accompanied by the production of pro-inflammatory cytokines to defend
the injured area against infection.

Platelet disorders can lead to abnormal bleeding. Most common types of genetic proposition of platelet disorders including disorder of platelet adhesion, aggregation, secretion, and procoagulant activity.

If your blood platelet count falls below the normal range from 150,000 to 450,000 platelets per microliter of circulating blood, you are considered thrombocytopenia.

Believe it or not, platelet count that falls below 10,000 platelets per microliter are dangerous. Epidemiologically, severe thrombocytopenia can be fatal.

 Most common symptoms of platelet disorders are unexplained bruising throughout the body, bleeding from your nose, mouth, or gums, under your skin, muscles, and joints and heavy or prolonged menstrual bleeding,

In severe cases, patients may also experience symptoms of vomiting blood,  blood in your feces and internal bleeding.

Conventionally, most common medication with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belongings to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. The veggie can be classified into two major groups, bush beans, and pole beans.

On finding a potent veggie for the prevention of cardiovascular disease, researchers investigated the common bean anti-platelet aggregation activity.

According to the tested analysis, common beans exerted a novel property in the inhibition of thrombotic cardiovascular events.

Furthermore, levels of adenosine 5′-diphosphate and arachidonic acid associated with platelet aggregation were also significantly reduced by the administration of bean extracts. 

Moreover, the surface expression of P-Selectin involved in cell adhesion molecules (CAM) on the surfaces of activated endothelial cells induced platelet aggregation also inhibited the beans extracts.

More precisely, the beans extract the modulates the expression of AKT hypo-phosphorylation decreases in the activation of platelets may be the mechanism underlying such effect.

Based on the findings, researchers said, " common beans are nutritional ingredients that help reduce the risk of cardiovascular diseases associated with platelet hyper-reactivity".

Taken altogether, green beans may process anti platelet aggression against the cardiovascular risk, pending to the confirmation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phaseolus vulgaris Exerts an Inhibitory Effect on Platelet Aggregation through AKT Dependent Way by Rosio Rodríguez-Azúa,1 Eduardo Fuentes Quinteros,2 Alexandra Olate-Briones,2,3 andRodrigo Moore-Carrasco. (PMC)